Evidence map›Paper›PMID 31734122›Full record

SynthesisJournal of the American Medical Directors Association2020

Prevalence of Hospital-Associated Disability in Older Adults: A Meta-analysis.

Christine Loyd, Alayne D Markland, Yue Zhang, Mackenzie Fowler, Sara Harper, Nicole C Wright, Christy S Carter, Thomas W Buford, Catherine H Smith, Richard Kennedy and 1 more

4 registry-linked trialsOpen access · greenAbstract readMeta-AnalysisReview
In one paragraph

Synthesis in Journal of the American Medical Directors Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 200 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
200citing papers in PubMed, 14 pooled it
13.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05484063 naunknown statusnot on this mapstarted 2022, after this paper: background citation

Help Optimise and Mobilise Elders (H.O.M.E)

TypeinterventionalSponsorJurongHealthRan2022 to 2023Enrolled90ConditionsMobility Limitation, Functional DisturbanceArmsMulticomponent, mobility-focused intervention
NCT06611228 narecruitingnot on this mapstarted 2024, after this paper: background citation

Optimizing Prevention of Hospital-acquired Disability Through Integrated Multidomain Interventions: the Age-IT Project

TypeinterventionalSponsorUniversity of Milano BicoccaRan2024 to 2027Enrolled288ConditionsFrailty Syndrome, AgingArmsMultidomain Interventions
NCT06820021 narecruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of a Strength-based Tailored-Exercise Program at Home (STEP@Home) on Health Outcomes of Geriatric Patients at Risk of Hospitalization-associated Functional Decline: A Sequential Mixed-method Study

TypeinterventionalSponsorThe University of Hong KongRan2025 to 2030Enrolled256ConditionsFrailty, GeriatricsArmsStrength-based Tailored-Exercise Program at Home (STEP@Home), Physical activity education
NCT06903832 recruitingnot on this mapstarted 2025, after this paper: background citation

Discharge Recommendations for Older Adults Using Physical Outcome Measure (DROP)

TypeobservationalSponsorNational University Hospital, SingaporeRan2025 to 2026Enrolled60ConditionsDischarge Planning, Older Adults (65 Years and Older), Acute Hospitalization, OUTCOME MEASURES
3 · Its place in the literature

Who cites it

200 citing papers in PubMed, 14 syntheses or guidelines pooled it, 351 citations in OpenAlex.

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  7. Admission avoidance hospital at home.The Cochrane database of systematic reviews · 2024
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  10. Exercise for acutely hospitalised older medical patients.The Cochrane database of systematic reviews · 2022
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140 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 1 institution in 1 country.

Christine LoydDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL; Birmingham/Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham Veterans Affairs Medical Center, Birmingham, AL.
Alayne D MarklandDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL; Birmingham/Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham Veterans Affairs Medical Center, Birmingham, AL. Electronic address: amarkland@uabmc.edu.
Yue ZhangDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Mackenzie FowlerDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Sara HarperDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Nicole C WrightDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL.
Christy S CarterDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Thomas W BufordDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL.
Catherine H SmithLister Hill Library of the Health Sciences, University of Alabama at Birmingham, Birmingham, AL.
Richard KennedyDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL; Birmingham/Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham Veterans Affairs Medical Center, Birmingham, AL.
Cynthia J BrownDepartment of Medicine, Division of Gerontology, Geriatrics, and Palliative Care, UAB School of Medicine, University of Alabama at Birmingham, Birmingham, AL; Birmingham/Atlanta Veterans Affairs Geriatric Research, Education, and Clinical Center, Birmingham Veterans Affairs Medical Center, Birmingham, AL.
University of Alabama at Birmingham · US

Funding

Mentored Experiences in Research, Instruction and Teaching (MERIT) Program - administrative supplementK12GM088010 · NIGMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI SCHNEIDER, DAVID ALAN · 2009 to 2024
$9.2M
Rehabilitation Research Resource to Enhance Clinical Trials (ReACT)P2CHD086851 · NICHD · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI BAMMAN, MARCAS M · 2015 to 2019
$7.1M
Biology or Management: Understanding Racial Differences in Post Fracture OutcomesK01AR068400 · NIAMS · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI WRIGHT, NICOLE C · 2017 to 2020
$508k
Impact of a Hospital Mobility Program on Function after DischargeI01RX001995 · VA · BIRMINGHAM VA MEDICAL CENTER · PI MARKLAND, ALAYNE DENISE · 2016 to 2021
–
NIAMS NIH HHS K01 AR068400NICHD NIH HHS P2C HD086851NIGMS NIH HHS K12 GM088010RRD VA I01 RX001995
6 · The paper itself

Abstract

objectivesHospital-associated disability (HAD), defined as loss of independence in activities of daily living (ADL) following acute hospitalization, is observed among older adults. The study objective is to determine overall prevalence of HAD among older adults hospitalized in acute care, and to assess the impact of study initiation year in moderation of prevalence.

designMeta-analysis of data collected from randomized trials, quasi-experimental, and prospective cohort studies. English-language searches to identify included studies were completed February 2018 and updated May 2018 of electronic databases and reference lists of studies and reviews. Included studies were human subjects investigations that measured ADL ≥2 time points before or during and after hospitalization and reported prevalence of ADL decline among older adults.

settingAcute care hospital units.

participantsAdults aged ≥65 years hospitalized in medical-surgical acute care; total sample size across all included studies was 7375.

methodsIndependence in ADL was assessed using the Katz Index of Independence in Activities of Daily Living and Barthel Index of Independence in Activities of Daily Living.

resultsRandom effects meta-analysis across included studies identified combined prevalence of HAD as 30% (95% CI 24%, 33%; P < .001). The effect of study initiation year on the prevalence rate was minimal. A large amount of heterogeneity was observed between studies, which may be due in part to nonstandardized measurement of ADL impairment or other methodological differences. CONCLUSIONS AND IMPLICATIONS: Hospitalization in acute care poses a significant risk to functional independence of older adults, and this risk is unchanged despite shorter lengths of stay. The evidence supports the continued need for hospital-based programs that provide assessment of functional ability and identification of at-risk older adults in order to better treat and prevent HAD.

Indexed as

Activities of Daily LivingPersons with DisabilitiesAgedHospitalsHumansPrevalenceProspective Studiesactivities of daily livingdisabilityHospitalizationolder adult

Identifiers

PMID31734122
PMCPMC7469431
OpenAlexW2984952065

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.