ArticleDrug and alcohol dependence2020
Interpersonal trauma exposure and startle reactivity to uncertain threat in individuals with alcohol use disorder.
Article in Drug and alcohol dependence, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed.
- Effects of oxytocin administration on fear-potentiated acoustic startle in co-occurring PTSD and alcohol use disorder: A randomized clinical trial.Psychiatry research · 2022Trial
- Longitudinal associations between binge drinking and changes in behavioral and neural threat reactivity in youth.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- Brief transdiagnostic cognitive behavioral therapy and expressive writing for hazardous drinking and posttraumatic stress symptoms among sexual and gender minority adults: Pilot trial protocol.Contemporary clinical trials communications · 2026Article
- Impact of Childhood Family Conflict on Adolescents' Startle Reactivity to Threat: The Moderating Role of Sensory Processing Sensitivity.Journal of adolescence · 2026Article
- Impact of behavioral inhibitory control and startle reactivity to uncertain threat on youth suicide risk.Psychophysiology · 2025Article
- Impact of handgun ownership and biological sex on startle reactivity to predictable and unpredictable threats.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2024Article
- Sleep quality impacts the link between reactivity to uncertain threat and anxiety and alcohol use in youth.Psychophysiology · 2024Article
- Subcortical serotonin 5HTNature communications · 2023Article
- Association between startle reactivity to uncertain threats and structural brain volume.Psychophysiology · 2022Article
- The role of PTSD symptom clusters and criterion in predicting future high-risk drug and alcohol use among returning veteran men and women.Psychological services · 2022Article
- Childhood Adversity and the Association Between Stress Sensitivity and Problematic Alcohol Use in Adults.Journal of traumatic stress · 2022Article
- Developmental trauma: Conceptual framework, associated risks and comorbidities, and evaluation and treatment.Frontiers in psychiatry · 2022Review
- Early Life Stress and Risks for Opioid Misuse: Review of Data Supporting Neurobiological Underpinnings.Journal of personalized medicine · 2021Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
Abstract
backgroundExposure to interpersonal trauma is highly prevalent within individuals with alcohol use disorder (AUD); however, the mechanisms underlying the pathway between trauma exposure and AUD are unclear. Preliminary evidence suggests that heightened reactivity to threats that are uncertain (U-threat) may characterize individuals with AUD and interpersonal trauma exposure and contribute to alcohol abuse within this subgroup of individuals; however, this hypothesis has yet to be tested.
methodThe aim of the study was to examine whether heightened reactivity to U-threat characterizes individuals with AUD and a history of interpersonal trauma. Specifically, the study compared defensive reactivity to U-threat (and predictable threat [P-threat]) in those with: 1) AUD and a history of interpersonal trauma (AUD + Trauma); 2) AUD and no history of interpersonal trauma (AUD-Trauma); and 3) matched controls. Participants (N = 77) completed a well-validated threat-of-shock task and startle eyeblink potentiation was collected as an index of aversive responding.
resultsResults revealed a group by threat condition interaction (F[4, 142] = 3.17, p = 0.03; η
conclusionsWithin individuals with AUD, those with a history of interpersonal trauma exposure may be a neurobiologically unique subtype characterized by exaggerated U-threat reactivity and high levels of anticipatory anxiety. Reactivity to U-threat may be a promising alcohol use prevention and intervention target for trauma-exposed individuals.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.