Evidence map›Paper›PMID 31733979›Full record

ArticleThe International journal on drug policy2019

Associations between perceived illicit fentanyl use and infectious disease risks among people who inject drugs.

Barrot H Lambdin, Ricky N Bluthenthal, Jon E Zibbell, Lynn Wenger, Kelsey Simpson, Alex H Kral

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in The International journal on drug policy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05977881 (Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade), which is not on this map. Cited by 79 papers.

0numbers the graph read from it
0cells of the map it votes in
79citing papers in PubMed
10.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05977881 nacompletednot on this mapstarted 2023, after this paper: background citation

Impact of a Novel HIV Peer Navigation and Overdose Prevention Intervention on Engagement in the HIV Prevention and Treatment Cascade

TypeinterventionalSponsorJohns Hopkins Bloomberg School of Public HealthRan2023 to 2026Enrolled493ConditionsHIV InfectionsArmsCHECKIT!
3 · Its place in the literature

Who cites it

79 citing papers in PubMed, 113 citations in OpenAlex.

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  13. Responding to an evolving crisis: Meeting the needs of a growing population who smoke their unregulated substances.Canadian journal of public health = Revue canadienne de sante publique · 2025
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  14. Brief Report: HIV Incidence Among People Who Inject Drugs, San Francisco, 2022.Journal of acquired immune deficiency syndromes (1999) · 2025
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19 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Barrot H LambdinRTI-International, San Francisco, CA, United States; University of California San Francisco, San Francisco, CA, United States; University of Washington, Seattle, WA, United States. Electronic address: blambdin@rti.org.
Ricky N BluthenthalUniversity of Southern California, Los Angeles, CA, United States.
Jon E ZibbellRTI-International, San Francisco, CA, United States.
Lynn WengerRTI-International, San Francisco, CA, United States.
Kelsey SimpsonUniversity of Southern California, Los Angeles, CA, United States.
Alex H KralRTI-International, San Francisco, CA, United States.
RTI International · USUniversity of Southern California · US

Funding

Preventing injection initiation: The Change The Cycle Randomized Controlled TrialR01DA038965 · NIDA · UNIVERSITY OF SOUTHERN CALIFORNIA · PI BLUTHENTHAL, RICKY N, KRAL, ALEXANDER H · 2015 to 2018
$3.0M
Individual and Structural Risk Factors for Opioid Overdose Associated with the Use and Supply of Illicitly Made FentanylR01DA046444 · NIDA · RESEARCH TRIANGLE INSTITUTE · PI ZIBBELL, JON ERIC · 2018 to 2020
$1.2M
NIDA NIH HHS R01 DA038965NIDA NIH HHS R01 DA046444
6 · The paper itself

Abstract

backgroundOver the last several years, fentanyl has been introduced into the illicit drug supply in the United States. While the impact of fentanyl on overdose fatalities is clear, the increase in fentanyl use may also be affecting drug use practices with implications for infectious disease transmission. We conducted a cross-sectional survey to explore associations of perceived illicit fentanyl use with opioid use frequency, injection frequency and syringe sharing among people who inject drugs in two California cities.

methodsPeople who inject drugs (PWID) were recruited from community settings in Los Angeles and San Francisco, CA from June 2017 to September 2018. Multivariable logistic regression was used to explore adjusted associations between perceived illicit fentanyl use and high frequency opioid use, high frequency injection and syringe sharing.

resultsAmong the 395 study participants, the median age of participants was 44 years; 74% of participants were cisgender male; 73% reported to be homeless; 61% lived in San Francisco and 39% in Los Angeles. The prevalence of perceived illicit fentanyl use in the past six months was 50.4% (95% confidence interval (CI): 45.4%-55.3%) among PWID. Findings from our adjusted logistic regression models suggested that people reporting perceived illicit fentanyl use had a greater odds of high frequency opioid use (adjusted odds ratio (aOR) = 2.36; 95% CI: 1.43-3.91; p = 0.001), high frequency injection (aOR = 1.84; 95% CI: 1.08-3.13; p = 0.03) and receptive syringe sharing (aOR = 2.16; 95% CI: 1.06-4.36; p = 0.03), as compared to people using heroin and other street drugs but not fentanyl.

conclusionPeople reporting perceived illicit fentanyl use were at increased risk for injection-related infectious disease risks. Actions must be taken to reduce these risks, including improved access to syringe service programs and opioid treatment and consideration of innovative approaches, such as supervised consumption services.

Indexed as

AdultCommunicable DiseasesCross-Sectional StudiesFemaleFentanylHumansIll-Housed PersonsIllicit DrugsLos AngelesMaleMiddle AgedNeedle SharingOpioid-Related DisordersPrevalenceRisk FactorsSan FranciscoFentanylIllicit DrugsHCVHIVIllicit fentanyl useInjection frequencySyringe sharing

Identifiers

PMID31733979
PMCPMC6949008
OpenAlexW2984687052

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.