ArticleNeuron2020
Resolving and Rescuing Developmental Miswiring in a Mouse Model of Cognitive Impairment.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- Are neurodegenerative diseases late-onset neurodevelopmental disorders? Tracing the developmental origins of neuronal vulnerability.Frontiers in neuroscience · 2026Review
- Prefrontal spine loss in neuropsychiatric disorders: circuit consequences for cognition.Frontiers in psychiatry · 2026Review
- A locus coeruleus-centric framework for novelty, salience, and gamma oscillations: implications for neurostimulation, aging, and disease.Frontiers in aging neuroscience · 2026Article
- Glia-to-glia serotonin signaling directs MMP-dependent infiltration for experience-dependent synapse pruning.PLoS biology · 2025Article
- Developmental Olfactory Dysfunction and Abnormal Odor Memory in Immune-ChallengedThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- AssessingFrontiers in immunology · 2025Review
- Development of Prefrontal Circuits and Cognitive Abilities.Cold Spring Harbor perspectives in biology · 2024Review
- Neuronal Coupling Modes Show Differential Development in the Early Cortical Activity Networks of Human Newborns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Review
- Reorganization of adolescent prefrontal cortex circuitry is required for mouse cognitive maturation.Neuron · 2024Article
- Altered neuroepithelial morphogenesis and migration defects in iPSC-derived cerebral organoids and 2D neural stem cells in familial bipolar disorder.Oxford open neuroscience · 2024Article
- Beyond anosmia: olfactory dysfunction as a common denominator in neurodegenerative and neurodevelopmental disorders.Frontiers in neuroscience · 2024Review
- Influence of Gender on Tau Precipitation in Alzheimer's Disease According to ATN Research Framework.Phenomics (Cham, Switzerland) · 2023Article
- Altered corollary discharge signaling in the auditory cortex of a mouse model of schizophrenia predisposition.Nature communications · 2023Article
- Generation and propagation of bursts of activity in the developing basal ganglia.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Loss of spines in the prelimbic cortex is detrimental to working memory in mice with early-life adversity.Molecular psychiatry · 2023Article
- Gamma oscillations provide insights into cortical circuit development.Pflugers Archiv : European journal of physiology · 2023Review
- Article
- How the sense of smell influences cognition throughout life.Neuroforum · 2022Review
- Article
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cognitive deficits, core features of mental illness, largely result from dysfunction of prefrontal networks. This dysfunction emerges during early development, before a detectable behavioral readout, yet the cellular elements controlling the abnormal maturation are still unknown. Here, we address this open question by combining in vivo electrophysiology, optogenetics, neuroanatomy, and behavioral assays during development in mice mimicking the dual genetic-environmental etiology of psychiatric disorders. We report that pyramidal neurons in superficial layers of the prefrontal cortex are key elements causing disorganized oscillatory entrainment of local circuits in beta-gamma frequencies. Their abnormal firing rate and timing relate to sparser dendritic arborization and lower spine density. Administration of minocycline during the first postnatal week, potentially acting via microglial cells, rescues the neuronal deficits and restores pre-juvenile cognitive abilities. Elucidation of the cellular substrate of developmental miswiring causing later cognitive deficits opens new perspectives for identification of neurobiological targets amenable to therapies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.