Evidence map›Paper›PMID 31733680›Full record

ReviewCritical care clinics2020

Procalcitonin: Where Are We Now?

Bachar Hamade, David T Huang

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care clinics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04507867 (Effect of a Nutritional Support System to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III), which is not on this map. Cited by 74 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
74citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04507867 nacompletednot on this map

Effect of a Nutritional Support System to Reduce Complications in Patients With Covid-19 and Comorbidities in Stage III

TypeinterventionalSponsorAnahuac UniversityRan2020 to 2021Enrolled80ConditionsCOVID19, Diabetes Mellitus, Hypertension, ObesityArmsNutritional support system (NSS), Conventional nutritional support designed by hospital nutritionists
3 · Its place in the literature

Who cites it

74 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
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14 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Bachar HamadeDepartment of Emergency Medicine, American University of Beirut Medical Center, 2nd Floor, Cairo Street, Beirut, Lebanon; Department of Critical Care Medicine, University of Pittsburgh Medical Center, 3550 Terrace Street, Room 651, Scaife Hall, Pittsburgh, PA 15261, USA.
David T HuangDepartments of Critical Care Medicine and Emergency Medicine, The MACRO (Multidisciplinary Acute Care Research Organization) and CRISMA (Clinical Research, Investigation, and Systems Modeling of Acute illness) Centers, University of Pittsburgh, 3550 Terrace Street, Room 606B, Scaife Hall, Pittsburgh, PA 15261, USA. Electronic address: huangdt@upmc.edu.

Funding

Procalcitonin Antibiotic Consensus Trial (ProACT)R01GM101197 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, DAVID TOM · 2013 to 2017
$5.0M
ProACT Planning GrantR34GM102696 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI HUANG, DAVID TOM · 2013 to 2013
$153k
NIGMS NIH HHS R01 GM101197NIGMS NIH HHS R34 GM102696
6 · The paper itself

Abstract

Procalcitonin is a biomarker that is generally elevated in bacterial infections. This review describes a conceptual framework for biomarkers using lessons from the history of troponin, applies this framework to procalcitonin with a review of observational studies and randomized trials in and out of the intensive care unit, and concludes with clinical recommendations and thoughts on how to test a test.

Indexed as

Anti-Bacterial AgentsBiomarkersHumansProcalcitoninRespiratory Tract InfectionsSepsisAnti-Bacterial AgentsBiomarkersProcalcitoninAntibioticsMortalityProcalcitoninRespiratory tract infectionSepsis

Identifiers

PMID31733680
PMCPMC6866676

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.