Evidence map›Paper›PMID 31733644›Full record

ArticleBMC cancer2019

Correlation between kidney transplantation and colorectal cancer in hemodialysis patients: A nationwide, retrospective, population-based cohort study.

Han-En Wang, Yu-Chan Liao, Je-Ming Hu, Wen-Chih Wu, Wan-Yun Chou, Yong-Chen Chen, Yu-Ching Chou, Chi-Feng Hung, Yu-Feng Tian, San-Lin You and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. Pooled it
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  3. Review
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  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Han-En WangDivision of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taiwan.
Yu-Chan LiaoSchool of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Je-Ming HuGraduate Institute of Medical Sciences, National Defense Medical Center, Taipei City, Taiwan.
Wen-Chih WuDepartment of Surgery, Suao and Yuanshan branches of Taipei Veterans General Hospital, Yilan County, Taiwan.
Wan-Yun ChouGraduate Institute of Life Sciences, National Defense Medical Center, Taipei City, Taiwan.
Yong-Chen ChenDepartment of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Yu-Ching ChouSchool of Public Health, National Defense Medical Center, Taipei City, Taiwan.
Chi-Feng HungDepartment of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Yu-Feng TianDivision of Colorectal Surgery, Department of Surgery, Chi-Mei Medical Center, Tainan City, Taiwan.
San-Lin YouDepartment of Medicine, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan.
Chien-An SunBig Data Research Center, College of Medicine, Fu-Jen Catholic University, New Taipei City, Taiwan. 040866@mail.fju.edu.tw.ORCID http://orcid.org/0000-0001-9041-0537
Fu Jen Catholic University · TWNational Defense Medical Center · TWTri-Service General Hospital · TWChi Mei Medical Center · TWTaipei Veterans General Hospital · TW

Funding

Chi Mei Medical Center 105-CM-FJU-09
6 · The paper itself

Abstract

backgroundKidney transplantation (KT) correlates with an increased risk of developing several malignancies; however, the risk of colorectal cancer (CRC) after KT remains debatable and has been marginally explored. Hence, in this nationwide, retrospective, population-based cohort study, we aimed to examine the correlation between KT and CRC in a large-scale population-based Chinese cohort.

methodsWe identified a total of 3739 regular hemodialysis patients undergoing KT (exposed cohort) and 42,324 hemodialysis patients not undergoing KT (non-exposed cohort) between 2000 and 2008 from Taiwan's National Health Insurance Research Database (NHIRD). Both cohorts were followed up from January 1, 2000, to the date of CRC diagnosis, death, or the end of 2013. Using Kaplan-Meier method, we measured the cumulative incidence of CRC in each cohort. Furthermore, Cox proportional hazards models were used to compute hazards ratios (HRs) and 95% confidence intervals (CIs) to estimate the correlation between KT and CRC in hemodialysis patients.

resultsThe Kaplan-Meier analysis revealed that the cumulative incidence of CRC was significantly higher in the exposed cohort than in the non-exposed cohort (log-rank test, P < 0.001). After adjusting for potential confounders, the exposed cohort exhibited a significantly increased risk of CRC compared with the non-exposed cohort (adjusted HR, 1.34; 95% CI, 1.11-1.62).

conclusionsHemodialysis patients undergoing KT have a significantly higher risk of CRC than those not undergoing KT. Cancer should continue to be a primary focus of prevention during KT.

Indexed as

ChinaColorectal NeoplasmsDatabases, FactualFemaleHumansIncidenceKidney TransplantationMaleMiddle AgedRenal DialysisRetrospective StudiesColorectal cancerHemodialysisKidney transplantationRetrospective cohort study

Identifiers

PMID31733644
PMCPMC6858634
OpenAlexW2982957704

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.