Evidence map›Paper›PMID 31733316›Full record

ArticleLife sciences2019

Intracardiac administration of ephrinA1-Fc preserves mitochondrial bioenergetics during acute ischemia/reperfusion injury.

Maria J Torres, Kelsey L McLaughlin, Randall H Renegar, Smrithi Valsaraj, K'Shylah S Whitehurst, Omar M Sharaf, Uma M Sharma, Julie L Horton, Brinda Sarathy, Justin C Parks and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Life sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Maria J TorresEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27834, USA.
Kelsey L McLaughlinEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27834, USA; Dept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Randall H RenegarDept of Anatomy and Cell Biology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Smrithi ValsarajDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
K'Shylah S WhitehurstDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Omar M SharafDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Uma M SharmaDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Julie L HortonEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27834, USA; Dept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Brinda SarathyDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Justin C ParksDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Jeffrey J BraultDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA; Dept of Kinesiology, College of Health and Human Performance, East Carolina University, Greenville, NC, 27834, USA.
Kelsey H Fisher-WellmanEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27834, USA; Dept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
P Darrell NeuferEast Carolina Diabetes and Obesity Institute, East Carolina University, Greenville, NC, 27834, USA; Dept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA.
Jitka A I ViragDept of Physiology, Brody School of Medicine, East Carolina University, Greenville, NC, 27834, USA. Electronic address: viragj@ecu.edu.
East Carolina University · US

Funding

Impact of organic cations on mitochondrial energetic driving forces and metabolic efficiencyR01DK110656 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2016 to 2019
$1.8M
CELLULAR ENERGETICS AS A REGULATOR OF MUSCLE MASS AND MITOCHONDRIAL CONTENT DURING MUSCLE ATROPHYR01AR070200 · NIAMS · INDIANA UNIVERSITY INDIANAPOLIS · PI BRAULT, JEFFREY J · 2017 to 2021
$1.6M
Redox Biology and Muscle Insulin SensitivityR01DK096907 · NIDDK · EAST CAROLINA UNIVERSITY · PI NEUFER, P DARRELL · 2012 to 2015
$1.4M
Salvaging the ischemic myocardium: the role ephrinA1/EphA bidirectional signalingR15HL124483 · NHLBI · EAST CAROLINA UNIVERSITY · PI VIRAG, JITKA A.I. · 2015 to 2015
$443k
NHLBI NIH HHS R15 HL124483NIAMS NIH HHS R01 AR070200NIDDK NIH HHS R01 DK096907NIDDK NIH HHS R01 DK110656
6 · The paper itself

Abstract

aimsIntracardiac injection of recombinant EphrinA1-Fc immediately following coronary artery ligation in mice reduces infarct size in both reperfused and non-reperfused myocardium, but the cellular alterations behind this phenomenon remain unknown. MAIN

methodsHerein, 10 wk-old B6129SF2/J male mice were exposed to acute ischemia/reperfusion (30minI/24hrsR) injury immediately followed by intracardiac injection of either EphrinA1-Fc or IgG-Fc. After 24 h of reperfusion, sections of the infarct margin in the left ventricle were imaged via transmission electron microscopy, and mitochondrial function was assessed in both permeabilized fibers and isolated mitochondria, to examine mitochondrial structure, function, and energetics in the early stages of repair. KEY

findingsAt a structural level, EphrinA1-Fc administration prevented the I/R-induced loss of sarcomere alignment and mitochondrial organization along the Z disks, as well as disorganization of the cristae and loss of inter-mitochondrial junctions. With respect to bioenergetics, loss of respiratory function induced by I/R was prevented by EphrinA1-Fc. Preservation of cardiac bioenergetics was not due to changes in mitochondrial JH SIGNIFICANCE: Collectively, these data suggest that intracardiac injection of EphrinA1-Fc protects cardiac function by preserving cardiomyocyte structure and mitochondrial bioenergetics, thus emerging as a potential therapeutic strategy in I/R injury.

Indexed as

AnimalsDisease Models, AnimalElectrophysiologic Techniques, CardiacEnergy MetabolismEphrin-A1MaleMiceMice, Inbred StrainsMitochondriaMitochondria, HeartMyocardial InfarctionMyocardial Reperfusion InjuryMyocardiumMyocytes, CardiacReperfusion InjuryEphrin-A1CardioprotectionephrinA1Mitochondrial bioenergeticsMyocardial infarction

Identifiers

PMID31733316
PMCPMC6898793
OpenAlexW2990509907

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.