Evidence map›Paper›PMID 31733195›Full record

ReviewClinica chimica acta; international journal of clinical chemistry2020

Polycystic ovarian syndrome: Correlation between hyperandrogenism, insulin resistance and obesity.

Xin Zeng, Yuan-Jie Xie, Ya-Ting Liu, Shuang-Lian Long, Zhong-Cheng Mo

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Clinica chimica acta; international journal of clinical chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05952882 (Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility), which is not on this map. Cited by 234 papers, 15 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
234citing papers in PubMed, 15 pooled it
34.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05952882 phase3unknown statusstarted 2023, after this paper: background citation

Effectiveness of the Combination Liraglutide and Metformin on Weight Loss, Metabolic - Endocrine Parameters and Pregnancy Rate in Women With Polycystic Ovarian Syndrome, Obesity and Infertility

Ran2023Enrolled188Registered outcomes60Posted comparisons0ConditionsInfertility, Female, Obesity, Polycystic Ovary SyndromeArmsLiraglutide + metformin, Metformin
PMID 18364705PMID 28681988PMID 19056992PMID 31229399PMID 29703793PMID 19841045PMID 24362411PMID 34583840PMID 11527911PMID 14688154PMID 17980364PMID 18068166other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

234 citing papers in PubMed, 15 syntheses or guidelines pooled it, 486 citations in OpenAlex.

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  3. The Relationship Between 2D:4D Digit Ratio and Polycystic Ovary Syndrome: A Systematic Review.American journal of human biology : the official journal of the Human Biology Council · 2026
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174 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Xin ZengClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, China.
Yuan-Jie XieClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, China; Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Institute of Reproductive Medicine, Yueyang, Hunan 416000, China.
Ya-Ting LiuClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, China; 2017 Grade Excellent Doctor Class of Hengyang Medical School, University of South China, Hengyang 421001, China.
Shuang-Lian LongClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, China. Electronic address: shlilong_sub@sina.com.
Zhong-Cheng MoClinical Anatomy & Reproductive Medicine Application Institute, Department of Histology and Embryology, University of South China, Hengyang, Hunan 421001, China; Hunan Province Innovative Training Base for Medical Postgraduates, University of South China and Yueyang Women & Children's Medical Center, Institute of Reproductive Medicine, Yueyang, Hunan 416000, China. Electronic address: zhchmo@hotmail.com.
University of South China · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Polycystic ovary syndrome (PCOS) is a complex and heterogeneous endocrine disease characterized by clinical or laboratorial hyperandrogenism, oligo-anovulation and metabolic abnormalities, including insulin resistance, excessive weight or obesity, type II diabetes, dyslipidemia and an increased risk of cardiovascular disease. The most significant clinical manifestation of PCOS is hyperandrogenism. Excess androgen profoundly affects granulosa cell function and follicular development via complex mechanisms that lead to obesity and insulin resistance. Most PCOS patients with hyperandrogenism have steroid secretion defects that result in abnormal folliculogenesis and failed dominant follicle selection. Hyperandrogenism induces obesity, hairy, acne, and androgenetic alopecia. These symptoms can bring great psychological stress to women. Drugs such as combined oral contraceptive pills, metformin, pioglitazone and low-dose spironolactone help improve pregnancy rates by decreasing androgen levels in vivo. Notably, PCOS is heterogeneous, and hyperandrogenism is not the only pathogenic factor. Obesity and insulin resistance aggravate the symptoms of hyperandrogenism, forming a vicious cycle that promotes PCOS development. Although numerous studies have been conducted, the definitive pathogenic mechanisms of PCOS remain uncertain. This review summarizes and discusses previous and recent findings regarding the relationship between hyperandrogenism, insulin resistance, obesity and PCOS.

Indexed as

Insulin ResistanceAndrogensFemaleHumansHyperandrogenismHypoglycemic AgentsMetforminObesityPioglitazonePolycystic Ovary SyndromeSpironolactoneAndrogensHypoglycemic AgentsMetforminPioglitazoneSpironolactoneFolliculogenesisHyperandrogenismOvaryPolycystic ovary syndrome

Identifiers

PMID31733195
OpenAlexW2987017313

What OpenQuestion holds

Texttitle and abstract
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.