Evidence map›Paper›PMID 31733190›Full record

ArticleDevelopmental biology2020

Nubp2 is required for cranial neural crest survival in the mouse.

Andrew DiStasio, David Paulding, Praneet Chaturvedi, Rolf W Stottmann

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Developmental biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Andrew DiStasioDivision of Human Genetics, OH, 45229, USA.
David PauldingDivision of Human Genetics, OH, 45229, USA.
Praneet ChaturvediDivision of Developmental Biology, Cincinnati Children's Hospital Medical Center, OH, 45229, USA.
Rolf W StottmannDivision of Human Genetics, OH, 45229, USA; Division of Developmental Biology, Cincinnati Children's Hospital Medical Center, OH, 45229, USA; Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH, 45229, USA; Shriner's Hospital for Children - Cincinnati, Cincinnati, OH, USA. Electronic address: Rolf.stottmann@cchmc.org.
Cincinnati Children's Hospital Medical Center · US

Funding

Forward genetic analysis of congenital craniofacial malformationsR01DE027091 · NIDCR · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI STOTTMANN, ROLF W · 2019 to 2023
$2.9M
Forward Genetic Analysis of Congenital Defects in Cortical Circuits and StructureR01NS085023 · NINDS · CINCINNATI CHILDRENS HOSP MED CTR · PI STOTTMANN, ROLF W · 2014 to 2018
$2.3M
Molecular Analysis of primary cilia proteins in human development and diseaseR35GM131875 · NIGMS · RESEARCH INST NATIONWIDE CHILDREN'S HOSP · PI STOTTMANN, ROLF W · 2019 to 2023
$2.0M
A Novel Function of Nubp2 in Craniofacial Development Through Regulation of Ciliary SignalingF31DE026676 · NIDCR · UNIVERSITY OF CINCINNATI · PI DISTASIO, ANDREW TYLER · 2017 to 2019
$128k
NIDCR NIH HHS F31 DE026676NIDCR NIH HHS R01 DE027091NIGMS NIH HHS R35 GM131875NINDS NIH HHS R01 NS085023
6 · The paper itself

Abstract

The N-ethyl-N-nitrosourea (ENU) ←forward genetic screen is a useful tool for the unbiased discovery of novel mechanisms regulating developmental processes. We recovered the dorothy mutation in such a screen designed to recover recessive mutations affecting craniofacial development in the mouse. Dorothy embryos die prenatally and exhibit many striking phenotypes commonly associated with ciliopathies, including a severe midfacial clefting phenotype. We used exome sequencing to discover a missense mutation in nucleotide binding protein 2 (Nubp2) to be causative. This finding was confirmed by a complementation assay with the dorothy allele and an independent Nubp2 null allele (Nubp2

Indexed as

AnimalsEmbryonic DevelopmentEthylnitrosoureaFemaleGTP-Binding ProteinsHigh-Throughput Screening AssaysMaleMesodermMiceMice, Inbred C57BLMutagenesisMutationNeural CrestPhenotypeSignal TransductionSkullEthylnitrosoureaGTP-Binding ProteinsNUBP2 protein, mouseWnt1 ProteinCiliaENU mutagenesisNeural crestNubp2

Identifiers

PMID31733190
PMCPMC6995770
OpenAlexW2987746876

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.