Evidence map›Paper›PMID 31733099›Full record

ArticleJournal of cellular and molecular medicine2020

Down-regulated lncRNA HOTAIR alleviates polycystic ovaries syndrome in rats by reducing expression of insulin-like growth factor 1 via microRNA-130a.

Bin Jiang, Min Xue, Dabao Xu, Jiayu Song, Shujuan Zhu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 54 citations in OpenAlex.

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  19. Research progress in lncRNA and its action as ceRNA in ovarian function as well as the relevant diseases.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Bin JiangDepartment of Gynaecology, The Third Xiangya Hospital of Central South University, Changsha, China.
Min XueDepartment of Gynaecology, The Third Xiangya Hospital of Central South University, Changsha, China.
Dabao XuDepartment of Gynaecology, The Third Xiangya Hospital of Central South University, Changsha, China.
Jiayu SongDepartment of Gynaecology, The Third Xiangya Hospital of Central South University, Changsha, China.
Shujuan ZhuDepartment of Gynaecology, The Third Xiangya Hospital of Central South University, Changsha, China.ORCID 0000-0002-4414-7640
Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It has been found that long noncoding RNA HOTAIR, microRNA-130a (miR-130a) and insulin-like growth factor 1 (IGF1) expression are associated with ovarian cancer, thus, we hypothesised that the HOTAIR/miR-130a/IGF1 axis might associate with endocrine disorders and biological behaviours of ovarian granulosa cells in rat models of polycystic ovary syndrome (PCOS). PCOS rat models were established by injection of dehydro-isoandrosterone, followed by treatment of si-HOTAIR, oe-HOTAIR, miR-130a mimics or miR-130a inhibitors. Serum hormonal levels were determined to evaluate endocrine conditions. The effect of HOTAIR and miR-130a on activities of isolated ovarian granulosa cells was assessed, as well as the involvement of IGF1.In the ovarian tissues and granulosa cells of PCOS rat models, highly expressed HOTAIR and IGF1 and poorly expressed miR-130a were identified. In response to oe-HOTAIR, serum levels of E

Indexed as

AnimalsApoptosisBase SequenceBinding, CompetitiveCell ProliferationCell SurvivalDisease Models, AnimalDown-RegulationFemaleGranulosa CellsInsulin-Like Growth Factor IMicroRNAsPolycystic Ovary SyndromeRats, Sprague-DawleyRNA, Long NoncodingHOTAIR long untranslated RNA, ratInsulin-Like Growth Factor IMicroRNAsMIRN130 microRNA, ratRNA, Long NoncodingCompetitive bindingEndocrineGranulosa cellHOTAIRInsulin-like growth factor 1MicroRNA-130aPolycystic ovaries syndromeTargeted inhibition

Identifiers

PMID31733099
PMCPMC6933321
OpenAlexW2988327243

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.