ArticlePlant biotechnology journal2020
TaDA1, a conserved negative regulator of kernel size, has an additive effect with TaGW2 in common wheat (Triticum aestivum L.).
Article in Plant biotechnology journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 82 papers.
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Who cites it
82 citing papers in PubMed, 144 citations in OpenAlex.
- Machine learning-guided multi-omics suggests iron-dependent hormonal signaling drives root morphological plasticity in wheat under temperature stress.The New phytologist · 2026Article
- The TaDof-2D-miR1832-TaP450-7A module regulates low-temperature-induced seed dormancy release in wheat.Plant communications · 2026Article
- Virus-induced transgene- and tissue culture-free heritable genome editing in tomato.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Identification and Validation of Stable Loci Underlying Productivity-Related Traits in Common Wheat.International journal of molecular sciences · 2026Article
- The miR171a-TaSCL6-1 Module Acts Downstream of miR164-Targeted TaNAC21/22 to Regulate Leaf Rust Resistance in Wheat.Plant biotechnology journal · 2026Article
- The ubiquitin receptor StDA1 negatively regulates aurantio-obtusin biosynthesis by mediating the degradation of the StHDR1 protein in Senna tora seeds.Communications biology · 2026Article
- Functional 5Bq allele is responsible for the compact spike phenotype in common wheat (Triticum aestivum L.).BMC plant biology · 2026Article
- Q allele overexpression and alternative splicing can improve wheat yield by increasing thousand-kernel weight and grain number per spike.BMC plant biology · 2026Article
- Integrated Multi-Omics Reveals the Molecular Basis Underlying Wheat Grain Development and IdentifiesPlants (Basel, Switzerland) · 2025Article
- Pangenome identification and functional characterization of AHL genes in wheat (Triticum aestivum L.) reveal the role of TaAHL67 in grain weight regulation.BMC plant biology · 2025Article
- Impact of Alien Chromosome Introgression fromPlants (Basel, Switzerland) · 2025Article
- Overexpression of TaCR4-A positively regulates grain size in Triticum aestivum.BMC plant biology · 2025Article
- Antagonistic effects of selection on alleles associated with seed size and seed dormancy in wheat.Genome biology · 2025Article
- A natural variation in the promoter of TaGDSL-7D contributes to grain weight and yield in wheat.Plant biotechnology journal · 2025Article
- Large-scale identification and association analysis of wheat grain weight genes using rice orthologs.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
- TaFT-D1 positively regulates grain weight by acting as a coactivator of TaFDL2 in wheat.Plant biotechnology journal · 2025Article
- Genetic identification and characterization of quantitative trait loci for wheat grain size-related traits independent of grain number per spike.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Review
- CRISPR/Cas9-mediated disruption of DA1 enhances both biomass yield and quality in poplar.Plant biotechnology journal · 2025Article
- Genomic analysis of Zhou8425B, a key founder parent, reveals its genetic contributions to elite agronomic traits in wheat breeding.Plant communications · 2025Article
- Fine mapping of stripe rust resistance gene YrAn1589 in common wheat using Wheat660K SNP array and BSR-Seq.TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik · 2025Article
22 more citing papers are in PubMed but not listed here.
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Kernel size is an important trait determining cereal yields. In this study, we cloned and characterized TaDA1, a conserved negative regulator of kernel size in wheat (Triticum aestivum). The overexpression of TaDA1 decreased the size and weight of wheat kernels, while its down-regulation using RNA interference (RNAi) had the opposite effect. Three TaDA1-A haplotypes were identified in Chinese wheat core collections, and a haplotype association analysis showed that TaDA1-A-HapI was significantly correlated with the production of larger kernels and higher kernel weights in modern Chinese cultivars. The haplotype effect resulted from a difference in TaDA1-A expression levels between genotypes, with TaDA1-A-HapI resulting in lower TaDA1-A expression levels. This favourable haplotype was found having been positively selected during wheat breeding over the last century. Furthermore, we demonstrated that TaDA1-A physically interacts with TaGW2-B. The additive effects of TaDA1-A and TaGW2-B on kernel weight were confirmed not only by the phenotypic enhancement arising from the simultaneous down-regulation of TaDA1 and TaGW2 expression, but also by the combinational haplotype effects estimated from multi-environment field data from 348 wheat cultivars. A comparative proteome analysis of developing transgenic and wild-type grains indicated that TaDA1 and TaGW2 are involved in partially overlapping but relatively independent protein regulatory networks. Thus, we have identified an important gene controlling kernel size in wheat and determined its interaction with other genes regulating kernel weight, which could have beneficial applications in wheat breeding.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.