Evidence map›Paper›PMID 31733065›Full record

ArticleNucleic acids research2020

PHI-base: the pathogen-host interactions database.

Martin Urban, Alayne Cuzick, James Seager, Valerie Wood, Kim Rutherford, Shilpa Yagwakote Venkatesh, Nishadi De Silva, Manuel Carbajo Martinez, Helder Pedro, Andy D Yates and 2 more

Open access · goldAbstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 201 papers.

0numbers the graph read from it
0cells of the map it votes in
201citing papers in PubMed
31.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

201 citing papers in PubMed, 352 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
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  8. Article
  9. Genomic and Functional Characterization of anLife (Basel, Switzerland) · 2026
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  10. Article
  11. Article
  12. Dual RNA-Seq Reveals Molecular Interactions BetweenFoods (Basel, Switzerland) · 2026
    Article
  13. Review
  14. Article
  15. Whole-Genome Sequencing of PathogenicJournal of fungi (Basel, Switzerland) · 2026
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

141 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Martin UrbanDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Alayne CuzickDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
James SeagerDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Valerie WoodCambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Kim RutherfordCambridge Systems Biology Centre and Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, UK.
Shilpa Yagwakote VenkateshMolecular Connections, Kandala Mansions, Kariappa Road, Basavanagudi, Bengaluru 560 004, India.
Nishadi De SilvaEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Manuel Carbajo MartinezEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Helder PedroEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Andy D YatesEuropean Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SD, UK.
Keywan Hassani-PakDepartment of Computational and Analytical Sciences, Rothamsted Research, Harpenden AL5 2JQ, UK.
Kim E Hammond-KosackDepartment of Biointeractions and Crop Protection, Rothamsted Research, Harpenden AL5 2JQ, UK.
Rothamsted Research · GBEuropean Bioinformatics Institute · GBUniversity of Cambridge · GB

Funding

Biotechnology and Biological Sciences Research Council BB/I000488/1Biotechnology and Biological Sciences Research Council BB/I001077/1
6 · The paper itself

Abstract

The pathogen-host interactions database (PHI-base) is available at www.phi-base.org. PHI-base contains expertly curated molecular and biological information on genes proven to affect the outcome of pathogen-host interactions reported in peer reviewed research articles. PHI-base also curates literature describing specific gene alterations that did not affect the disease interaction phenotype, in order to provide complete datasets for comparative purposes. Viruses are not included, due to their extensive coverage in other databases. In this article, we describe the increased data content of PHI-base, plus new database features and further integration with complementary databases. The release of PHI-base version 4.8 (September 2019) contains 3454 manually curated references, and provides information on 6780 genes from 268 pathogens, tested on 210 hosts in 13,801 interactions. Prokaryotic and eukaryotic pathogens are represented in almost equal numbers. Host species consist of approximately 60% plants (split 50:50 between cereal and non-cereal plants), and 40% other species of medical and/or environmental importance. The information available on pathogen effectors has risen by more than a third, and the entries for pathogens that infect crop species of global importance has dramatically increased in this release. We also briefly describe the future direction of the PHI-base project, and some existing problems with the PHI-base curation process.

Indexed as

Databases, FactualAlgorithmsAnimalsAntifungal AgentsBiological AssayCommunicable DiseasesComputational BiologyCrops, AgriculturalData ManagementGenome, PlantHost-Pathogen InteractionsHumansInternetPhenotypePlantsSearch EngineAntifungal Agents

Identifiers

PMID31733065
PMCPMC7145647
OpenAlexW2985884608

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.