Evidence map›Paper›PMID 31733057›Full record

ArticleNucleic acids research2020

Xenbase: deep integration of GEO & SRA RNA-seq and ChIP-seq data in a model organism database.

Joshua D Fortriede, Troy J Pells, Stanley Chu, Praneet Chaturvedi, DongZhuo Wang, Malcom E Fisher, Christina James-Zorn, Ying Wang, Mardi J Nenni, Kevin A Burns and 5 more

Abstract read
In one paragraph

Article in Nucleic acids research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Xenbase: A Guide to the Xenopus Genetics and Genomics Knowledgebase.Methods in molecular biology (Clifton, N.J.) · 2026
    Article
  4. Article
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  8. Article
  9. Article
  10. Using Xenopus to discover new candidate genes involved in BOR and other congenital hearing loss syndromes.Journal of experimental zoology. Part B, Molecular and developmental evolution · 2024
    Review
  11. Review
  12. Article
  13. The sulfotransferase XB5850668.L is required to apportion embryonic ectodermal domains.Developmental dynamics : an official publication of the American Association of Anatomists · 2023
    Article
  14. Article
  15. Article
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  19. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Joshua D FortriedeCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Troy J PellsDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Stanley ChuDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Praneet ChaturvediCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
DongZhuo WangDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Malcom E FisherCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Christina James-ZornDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Ying WangCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Mardi J NenniCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Kevin A BurnsCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Vaneet S LotayDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Virgilio G PonferradaCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Kamran KarimiDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.
Aaron M ZornCincinnati Children's Hospital, Division of Developmental Biology, 3333 Burnet Avenue, Cincinnati, OH 45229, USA.
Peter D VizeDepartments of Biological Sciences and Computer Science, University of Calgary, Calgary, Alberta T2N1N4, Canada.

Funding

Xenbase: the Xenopus Model Organism KnowledgebaseP41HD064556 · NICHD · CINCINNATI CHILDRENS HOSP MED CTR · PI Aaron M Zorn · 2010 to 2026
$24.9M
NICHD NIH HHS P41 HD064556Wellcome Trust
6 · The paper itself

Abstract

Xenbase (www.xenbase.org) is a knowledge base for researchers and biomedical scientists that employ the amphibian Xenopus as a model organism in biomedical research to gain a deeper understanding of developmental and disease processes. Through expert curation and automated data provisioning from various sources Xenbase strives to integrate the body of knowledge on Xenopus genomics and biology together with the visualization of biologically significant interactions. Most current studies utilize next generation sequencing (NGS) but until now the results of different experiments were difficult to compare and not integrated with other Xenbase content. Xenbase has developed a suite of tools, interfaces and data processing pipelines that transforms NCBI Gene Expression Omnibus (GEO) NGS content into deeply integrated gene expression and chromatin data, mapping all aligned reads to the most recent genome builds. This content can be queried and visualized via multiple tools and also provides the basis for future automated 'gene expression as a phenotype' and gene regulatory network analyses.

Indexed as

Databases, GeneticGenomicsSoftwareAnimalsChromatin Immunoprecipitation SequencingGene ExpressionGene Regulatory NetworksHigh-Throughput Nucleotide SequencingRNA-SeqUser-Computer InterfaceXenopus

Identifiers

PMID31733057
PMCPMC7145613

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.