SynthesisCancer medicine2020
Role of human papillomavirus in laryngeal squamous cell carcinoma: A meta-analysis of cohort study.
Synthesis in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 4 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Human papillomavirus infection and non-oropharyngeal head and neck cancers: an umbrella review of meta-analysis.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2023Pooled it
- The effect of HPV DNA and p16 status on the prognosis of patients with hypopharyngeal carcinoma: a meta-analysis.BMC cancer · 2022Pooled it
- Immunotherapy Advances in Locally Advanced and Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma and Its Relationship With Human Papillomavirus.Frontiers in immunology · 2021Pooled it
- Role of human papillomavirus in laryngeal squamous cell carcinoma: A meta-analysis of cohort study.Cancer medicine · 2020Pooled it
- Immunohistochemical Study of the Tumor Immune Microenvironment in Laryngeal Squamous Cell Carcinoma and Its Prognostic Implications.Diagnostics (Basel, Switzerland) · 2026Article
- HPV-positive cancers at uncommon sites: a narrative review.Oncology reviews · 2026Review
- The prevalence of human papillomavirus and Epstein-Barr virus among laryngoscopy referrals in Northeastern Iran.BMC infectious diseases · 2025Article
- Evolution in Laryngeal Cancer Mortality at the National and Subnational Level in Romania with 2030 Forecast.Medicina (Kaunas, Lithuania) · 2025Article
- Clinical characteristics and prognostic impact of HPV infection in head and neck cancer patients in china: a nationwide multicenter study.Infectious agents and cancer · 2025Article
- Unraveling resistance to immune checkpoint inhibitors in HNSCC: from mechanisms to combination therapies.Cancer drug resistance (Alhambra, Calif.) · 2025Review
- P53 and pRB induction improves response to radiation therapy in HPV-positive laryngeal squamous cell carcinoma.Clinics (Sao Paulo, Brazil) · 2024Article
- The Follicular Dendritic Cells and HPV 18 Interrelation in Head and Neck Squamous Cell Carcinomas of the Larynx.Medicina (Kaunas, Lithuania) · 2023Article
- Article
- Human papillomavirus in oral squamous cell carcinoma using p16 and its co-relationship with cervical lymph node metastasis and clinicopathological parameters.Dental research journal · 2023Article
- Molecular detection of human papillomavirus-16 among Sudanese patients diagnosed with squamous cell carcinoma and salivary gland carcinoma.BMC research notes · 2021Article
- Human papilloma virus-associated metachronous squamous cell carcinoma of the larynx and uterine cervix: Case report and review of the literature.Gynecologic oncology reports · 2020Article
- HPV genotyping in head and neck cancer: Insights from a Colombian cohort.Brazilian journal of otorhinolaryngologyArticle
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the association of human papilloma virus (HPV) infection with prognosis, specifically overall survival (OS) and disease-free survival (DFS), in laryngeal squamous cell carcinoma (LSCC) patients.
methodA systematic review and meta-analysis were performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. LSCC was confirmed on the basis of histopathology, whereas HPV status was confirmed by polymerase chain reaction.
resultsA total of 6539 articles were initially searched from 8 databases, of which 11 studies were eligible for our review. A total of 1442 LSCC cases were included in this analysis. Eight studies examined 3-year OS for LSCC. The pooled hazard ratio (HR) from the 8 studies was 0.29 (95% CI: 0.25-0.33). There was a statistically significant difference in 3-year OS between the HPV-negative and -positive groups, with the latter having a better survival. There was no statistically significant differences in 5- and 10-year OS. Five studies examined 3- and 5-year DFS for LSCC, whereas only 3 studies examined 10-year DFS. There was no statistically significant difference in 3-, 5-, and 10-year DFS between the HPV groups.
conclusionThis study evaluated the survival impact of HPV infection in LSCC patients. The OS of the HPV-positive group was better than that of the HPV-negative group in terms of short-term survival. Compared with the HPV-negative group, the HPV-positive group had a better trend of DFS, suggesting that a larger sample size and further exploration of the pathology and local control of HPV-positive tumors are needed.
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