ArticleEnvironmental science and pollution research international2019
Neuropathological lesions in the brains of goats in North-Western Nigeria: possible impact of artisanal mining.
Article in Environmental science and pollution research international, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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3 citing papers in PubMed, 14 citations in OpenAlex.
- Article
- Cobalt-induced neuro-behavioural alterations are accompanied by profound Purkinje cell and gut-associated responses in rats.Environmental analysis, health and toxicology · 2023Article
- Neuroecotoxicology: Effects of environmental heavy metal exposure on the brain of African giant rats and the contribution of vanadium to the neuropathology.IBRO neuroscience reports · 2022Article
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5 authors at 2 institutions in 1 country.
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Abstract
Indiscriminate small-scale artisanal gold mining activities were reported to have caused anthropogenic heavy metal environmental pollution in Zamfara State, north-western Nigeria. There is little or no information on the neurotoxic effects and related neuropathological lesions due to environmental pollution in the animal population. Therefore, this work investigated the concentration of heavy metal and associated lesions in the brain of goats around an artisanal mining site in Zamfara. Brain samples were collected from 40 goats at slaughter slabs in Bagega (Zamfara State) while 15 goats with the same demography but without a history of environmental exposure at the time of this study served as controls. The concentration of lead and cadmium in brain tissue and histopathologic changes were assessed using atomic absorption spectrophotometry, histology and immunohistochemistry. The metal concentrations were significantly higher in exposed goats than in the unexposed animals. Cresyl violet staining and glial fibrillary acidic protein (GFAP) immunohistochemistry indicated chromatolysis and increased astrocytic activity respectively in the exposed goats. This study is of epidemiological importance as it shows a generalised increase of the metal concentrations in the brain of goats exposed to artisanal mining in Zamfara, north-western Nigeria. This could have health effects on the animals associated with nervous co-ordination, growth and development and as a good sentinel for pathogenesis of the heavy metal exposure.
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