ArticleAdvances in experimental medicine and biology2019
Biologically Defined or Biologically Informed Traits Are More Heritable Than Clinically Defined Ones: The Case of Oral and Dental Phenotypes.
Article in Advances in experimental medicine and biology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Inflammasome targeting for periodontitis prevention is sex dependent.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Precision Medicine in Oral Health and Diseases: A Systematic Review.Journal of personalized medicine · 2023Review
- Precision periodontal care: from omics discoveries to chairside diagnostics.Clinical oral investigations · 2023Review
- Phenotype Harmonization in the GLIDE2 Oral Health Genomics Consortium.Journal of dental research · 2022Article
- Interferon activated gene 204 protects against bone loss in experimental periodontitis.Journal of periodontology · 2022Article
- Distinct Microbial Signatures between Periodontal Profile Classes.Journal of dental research · 2021Article
- Periodontitis and Risk of Diabetes in the Atherosclerosis Risk In Communities (ARIC) Study: A BMI-Modified Association.The Journal of clinical endocrinology and metabolism · 2021Article
- Science for the Next Century: Deep Phenotyping.Journal of dental research · 2021Article
- IL-1B(3954) polymorphism and red complex bacteria increase IL-1β (GCF) levels in periodontitis.Journal of periodontal research · 2021Article
- Periodontal disease, undiagnosed diabetes, and body mass index: Implications for diabetes screening by dentists.Journal of the American Dental Association (1939) · 2021Article
- Cohort Profile: ZOE 2.0-A Community-Based Genetic Epidemiologic Study of Early Childhood Oral Health.International journal of environmental research and public health · 2020Article
- Grand Challenges in Oral Infections and Microbes.Frontiers in oral health · 2020Article
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Authors and funding
7 authors.
Funding
Abstract
The genetic basis of oral health has long been theorized, but little information exists on the heritable variance in common oral and dental disease traits explained by the human genome. We sought to add to the evidence base of heritability of oral and dental traits using high-density genotype data in a well-characterized community-based cohort of middle-age adults. We used genome-wide association (GWAS) data combined with clinical and biomarker information in the Dental Atherosclerosis Risk In Communities (ARIC) cohort. Genotypes comprised SNPs directly typed on the Affymetrix Genome-Wide Human SNP Array 6.0 chip with minor allele frequency of >5% (n = 656,292) or were imputed using HapMap II-CEU (n = 2,104,905). We investigated 30 traits including "global" [e.g., number of natural teeth (NT) and incident tooth loss], clinically defined (e.g., dental caries via the DMFS index, periodontitis via the CDC/AAP and WW17 classifications), and biologically informed (e.g., subgingival pathogen colonization and "complex" traits). Heritability (i.e., variance explained; h
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