Evidence map›Paper›PMID 31732920›Full record

ArticleCerebellum (London, England)2020

Posterior Fossa Arachnoid Cyst in a Pediatric Population is Associated with Social Perception and Rest Cerebral Blood Flow Abnormalities.

Elza Rechtman, Stephanie Puget, Ana Saitovitch, Hervé Lemaitre, Ludovic Fillion, Jean-Marc Tacchella, Jennifer Boisgontier, Marie-Laure Cuny, Nathalie Boddaert, Monica Zilbovicius

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Cerebellum (London, England), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02165410 (MRI Study of Cerebral Blood Flow in Development Disorders in Children), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02165410 nacompletednot on this map

MRI Study of Cerebral Blood Flow in Development Disorders in Children

TypeinterventionalSponsorAssistance Publique - Hôpitaux de ParisRan2013 to 2023Enrolled115ConditionsAutismArmsASL-MRI, Diffusion tensor imaging (diffusion MRI), Resting state MRI, Eye-tracking, Cognitive profile
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Elza RechtmanINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France. elza.rechtman@mssm.edu.ORCID http://orcid.org/0000-0002-5034-6048
Stephanie PugetDepartment of Pediatric Neurosurgery, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Pres Sorbonne Paris Cité, Paris, France.
Ana SaitovitchINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Hervé LemaitreINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Ludovic FillionINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Jean-Marc TacchellaINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Jennifer BoisgontierINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Marie-Laure CunyDepartment of Pediatric Neurosurgery, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Pres Sorbonne Paris Cité, Paris, France.
Nathalie BoddaertINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Monica ZilboviciusINSERM U1000, Department of Pediatric Radiology, Hôpital Necker Enfants Malades, AP-HP, University René Descartes, Institut Imagine and UMR 1163, Paris, France.
Hôpital Necker-Enfants Malades · FRDélégation Paris 5 · FRUniversité Paris-Sud · FR

Funding

Fondation de France (FR) 2011-00023952Fondation Orange N/A
6 · The paper itself

Abstract

Posterior fossa arachnoid cysts (PFAC) may produce not only neurological symptoms but also other symptoms still poorly understood such as behavioral and learning deficits, awkwardness, and difficulties in social interaction. These subtle social impairments have not been formally described and their underlying brain mechanisms remain unknown. In the present case-control study, we aimed to empirically characterize social impairments in a pediatric population with PFAC using eye tracking. In addition, we investigated putative functional cortical abnormalities in these children using arterial spin labeling magnetic resonance imaging. Overall, 15 patients with PFAC (3f, age = 9.4 ± 4 years) and 43 typically developing volunteer children (16f, age = 9.3 ± 3.6 years) were enrolled in this study. Eye tracking was used to record gaze patterns during visualization of social interaction scenes. Viewing times to faces of characters and non-social background were analyzed. A voxel-wise whole-brain analysis was performed to investigate rest cerebral blood flow (CBF) abnormalities. Significantly reduced viewing time to faces was observed in patients compared with controls (p < 0.01). A ROC curve analysis revealed that 30% of PFAC patients presented viewing time to the face lower than the cutoff, while none of the controls did. The whole-brain analysis revealed a significant decrease in rest CBF in PFAC patients compared with controls bilaterally in the superior temporal gyrus and the temporoparietal junction (TPJ) (p < 0.05 FWE). These results suggest that early life PFAC may have an impact on functional activity of the temporal lobe, which could be associated with social perception deficits.

Indexed as

Social PerceptionAdolescentArachnoid CystsCerebrovascular CirculationChildChild, PreschoolCranial Fossa, PosteriorEye MovementsFemaleHumansMagnetic Resonance ImagingMalePhotic StimulationRestArachnoid cystCerebellumCerebral blood flowEye trackingNeuroimagingSocial Perception

Identifiers

PMID31732920
OpenAlexW2982989437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.