Evidence map›Paper›PMID 31732918›Full record

Observational studyJournal of cardiovascular translational research2020

Interaction Between Diabetes Mellitus and Platelet Reactivity in Determining Long-Term Outcomes Following Percutaneous Coronary Intervention.

Fabio Mangiacapra, Edoardo Bressi, Iginio Colaiori, Elisabetta Ricottini, Ilaria Cavallari, Marialessia Capuano, Michele Matia Viscusi, Silvia Spoto, Emanuele Barbato, Germano Di Sciascio

Abstract readObservational Study
PubMed Publisher
In one paragraph

Observational study in Journal of cardiovascular translational research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Clopidogrel-Mediated P2YJACC. Basic to translational science · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Fabio MangiacapraUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy. f.mangiacapra@unicampus.it.ORCID 0000-0002-3505-0716
Edoardo BressiUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Iginio ColaioriUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Elisabetta RicottiniUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Ilaria CavallariUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Marialessia CapuanoUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Michele Matia ViscusiUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.
Silvia SpotoUnit of Internal Medicine, Department of Medicine, Campus Bio-Medico University, Rome, Italy.
Emanuele BarbatoDepartment of Advanced Biomedical Sciences, University of Naples Federico II, Naples, Italy.
Germano Di SciascioUnit of Cardiovascular Science, Department of Medicine, Campus Bio-Medico University, Via Álvaro del Portillo,, 200-00128, Rome, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Diabetes mellitus (DM) is an independent predictor of adverse outcomes in patients with coronary artery disease (CAD). We investigated the interaction between DM and high platelet reactivity (HPR) in determining long-term clinical outcomes after percutaneous coronary intervention (PCI). We enrolled 500 patients who were divided based on the presence of DM and HPR. Primary endpoint was the occurrence of major adverse clinical events (MACE) at 5 years. Patients with both DM and HPR showed the highest estimates of MACE (37.9%, log-rank p < 0.001), all-cause death (15.5%, log-rank p = 0.022), and non-fatal myocardial infarction (25.9%, log-rank p < 0.001). At Cox proportional hazard analysis, the coexistence of DM and HPR was an independent predictor of MACE (HR 3.46, 95% CI 1.67-6.06, p < 0.001). Among patients with stable CAD undergoing elective PCI and treated with aspirin and clopidogrel, the combination of DM and HPR identifies a cohort of patients with the highest risk of MACE at 5 years.

Indexed as

Diabetes MellitusDual Anti-Platelet TherapyPercutaneous Coronary InterventionAgedAspirinClopidogrelCoronary Artery DiseaseCoronary ThrombosisDrug ResistanceFemaleHumansMaleMiddle AgedMyocardial InfarctionPlatelet AggregationPlatelet Aggregation InhibitorsAspirinClopidogrelPlatelet Aggregation InhibitorsCoronary artery diseaseDiabetes mellitusPercutaneous coronary interventionPlatelet function

Identifiers

PMID31732918

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.