Evidence map›Paper›PMID 31732777›Full record

ArticleEuropean radiology2020

Ultrasound malignancy risk stratification of thyroid nodules based on the degree of hypoechogenicity and echotexture.

Ji Ye Lee, Dong Gyu Na, So Jin Yoon, Hye Yun Gwon, Wooyul Paik, Taeeun Kim, Jin Yub Kim

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Article in European radiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it.

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4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ji Ye LeeDepartment of Radiology, Eulji Medical Center, Seoul, 01830, Republic of Korea.
Dong Gyu NaDepartment of Radiology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea. nndgna@gmail.com.ORCID http://orcid.org/0000-0001-6422-1652
So Jin YoonDepartment of Radiology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea.
Hye Yun GwonDepartment of Radiology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea.
Wooyul PaikDepartment of Radiology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea.
Taeeun KimDepartment of Pathology, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea.
Jin Yub KimDivision of Endocrinology and Metabolism, Department of Internal Medicine, Gangneung Asan Hospital, College of Medicine, University of Ulsan, Gangneung, 25440, Republic of Korea.

Funding

Gangneung Asan Hospital 2018-C03
6 · The paper itself

Abstract

objectivesThe ultrasound (US) lexicon of nodule echogenicity and echotexture is one of the major differences among various risk stratification systems of thyroid nodules. This study aimed to stratify the US malignancy risk of thyroid nodules based on their degree of hypoechogenicity and echotexture. MATERIAL AND

methodsThis retrospective study included a total of 2255 consecutive thyroid nodules (≥ 1 cm) with final diagnoses (malignancy rate, 13%) from 2011 to 2016. Thyroid nodules were stratified according to the US degree of hypoechogenicity (mild, moderate, or marked hypoechogenicity) and echotexture (homogeneous vs. heterogeneous). The calculated malignancy risk was compared between each category.

resultsThere was no significant difference of malignancy risk between the homogeneous markedly hypoechoic and moderately hypoechoic nodules (p ≥ .18). However, the malignancy risks of markedly and moderately hypoechoic nodules were significantly higher than those of mildly hypoechoic nodules (p < .001). Heterogeneous predominantly hypoechoic thyroid nodules showed a significantly higher malignancy risk than predominantly iso- or hyperechoic thyroid nodules (p < .001). There were no significant differences of malignancy risk between heterogeneous predominantly hypoechoic and homogeneous hypoechoic nodules according to the degree of hypoechogenicity (p ≥ .12) and between heterogeneous predominantly iso- or hyperechoic nodules and homogeneous iso- or hyperechoic thyroid nodules (p = .36).

conclusionsThe malignancy risk of nodule hypoechogenicity is stratified as mild vs. moderate to marked hypoechogenicity, and the malignancy risk of nodules with heterogeneous echotexture is stratified by the predominant echogenicity of the nodules. KEY POINTS: • Thyroid nodule echogenicity is categorized as marked, moderate, or mild hypoechogenicity and iso- or hyperechogenicity with the reference standard of adjacent thyroid tissue and anterior neck muscles. • The malignancy risk of thyroid nodule echogenicity is stratified as iso- or hyperechoic vs. mild vs. moderate or marked hypoechogenicity. • The malignancy risk of nodules with heterogeneous echotexture is stratified by the predominant echogenicity.

Indexed as

AdultAgedAged, 80 and overFemaleHumansMaleMiddle AgedNeoplasm StagingRetrospective StudiesRisk AssessmentThyroid GlandThyroid NeoplasmsThyroid NoduleUltrasonographyYoung AdultBiopsyCytologyThyroid glandThyroid noduleUltrasonography

Identifiers

PMID31732777

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.