ArticleAge and ageing2019
Investigation of a possible association of potentially inappropriate medication for older adults and frailty in a prospective cohort study from Germany.
Article in Age and ageing, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 1 of them a synthesis that pooled it.
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Who cites it
24 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Current evidence on the impact of medication optimization or pharmacological interventions on frailty or aspects of frailty: a systematic review of randomized controlled trials.European journal of clinical pharmacology · 2021Pooled it
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- Trial
- Development and Validation of a Nomogram to Predict the Risk of Potentially Inappropriate Medication Use in Older Outpatients with Depression.Journal of clinical medicine · 2026Article
- A qualitative study on the challenges in deprescribing for elderly patients with polypharmacy.Frontiers in medicine · 2026Article
- Assessing potentially inappropriate medication use among older adults in Central and Eastern Europe.Annals of medicine · 2025Article
- Medication Use by Older Adults with Frailty: A Scoping Review.Pharmacy (Basel, Switzerland) · 2025Review
- SHIP-AGE: Frailty, renal function, and multi-component primary care in rural Mecklenburg-West Pomerania (MV-FIT)- study protocol.PloS one · 2025Observational
- Investigating Frailty, Polypharmacy, Malnutrition, Chronic Conditions, and Quality of Life in Older Adults: Large Population-Based Study.JMIR public health and surveillance · 2024Article
- Association between frailty and inappropriate prescribing in elderly patients admitted to an Acute Care of the Elderly Unit.Aging medicine (Milton (N.S.W)) · 2024Article
- Prediction of physiological state, cognition, sensory function, and biomarkers for frailty in patients aged 55 years or more with schizophrenia.Nursing open · 2023Article
- Association of Potentially Inappropriate Medication Classes with Mortality Risk Among Older Adults Initiating Hemodialysis.Drugs & aging · 2023Article
- Frailty and Potentially Inappropriate Prescribing in Older People with Polypharmacy: A Bi-Directional Relationship?Drugs & aging · 2022Review
- The patterns and implications of potentially suboptimal medicine regimens among older adults: a narrative review.Therapeutic advances in drug safety · 2022Review
- Frailty among inpatients with Schizophrenia: Status, influencing factors, and their correlation with quality of life.Frontiers in psychiatry · 2022Article
- Inclusion of Potentially Inappropriate Medicines for the Older Adults in the Brazilian Consensus in Accordance with International Criteria.Clinical interventions in aging · 2022Article
- Improving medication adherence and effective prescribing through a patient-centered prescription model in patients with multimorbidity.European journal of clinical pharmacology · 2022Article
- Risk of Potentially Inappropriate Medications in Adults With CKD: Findings From the Chronic Renal Insufficiency Cohort (CRIC) Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Observational
- Potentially Inappropriate Medication Prescribing Detected by Computer Algorithm among Older Patients: Results from the MAPT Study.Pharmacy (Basel, Switzerland) · 2021Article
- Preoperative medication use and development of postoperative delirium and cognitive dysfunction.Clinical and translational science · 2021Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivepotentially inappropriate medications (PIMs) are commonly defined as drugs that should be avoided in older adults because they are considered to have a negative risk-benefit ratio. PIMs are suspected to increase the risk for frailty, but this has yet to be examined.
designprospective population-based cohort study. SETTING AND
participantsa German cohort of community-dwelling older adults (≥60 years) was followed from October 2008 to September 2016.
methodsin propensity score-adjusted logistic and Cox regression models, associations between baseline PIM use and prevalent/incident frailty were investigated. Frailty was assessed using the definition by Fried and co-workers, PIM were defined with the 2015 BEERS criteria, the BEERS criteria to avoid in cognitively impaired patients (BEERS dementia PIM), the EU(7)-PIM and the PRISCUS list.
resultsof 2,865 participants, 261 were frail at baseline and 423 became frail during follow-up. Only BEERS dementia PIM use was statistically significantly associated with prevalent frailty (odds ratio (95% confidence interval), 1.51 (1.04-2.17)). The strength of the association was comparable for all frailty components. Similarly, in longitudinal analyses, only BEERS dementia PIM use was associated with incident frailty albeit not statistically significant (hazard ratio, 1.19 (0.84-1.68)).
conclusionsthe association of PIM use and frailty seems to be restricted to drug classes, which can induce frailty symptoms (anticholinergics, benzodiazepines, z-substances and antipsychotics). Physicians are advised to perform frailty assessments before and after prescribing these drug classes to older patients and to reconsider treatment decisions in case of negative performance changes.
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