Evidence map›Paper›PMID 31732717›Full record

ReviewNature reviews. Molecular cell biology2020

The functional universe of membrane contact sites.

William A Prinz, Alexandre Toulmay, Tamas Balla

Abstract readReview
In one paragraph

Review in Nature reviews. Molecular cell biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 428 papers.

0numbers the graph read from it
0cells of the map it votes in
428citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

428 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Article
  7. Ion transport as a determinant of membrane fusion and fission.Nature structural & molecular biology · 2026
    Review
  8. Review
  9. Review
  10. Review
  11. Article
  12. Hypertensive mt. tRNARedox biology · 2026
    Article
  13. Monitoring fatty acid trafficking duringbioRxiv : the preprint server for biology · 2026
    Article
  14. Review
  15. Review
  16. Review
  17. Review
  18. Article
  19. Article
  20. Article

368 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

William A PrinzNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA. wp53m@nih.gov.ORCID http://orcid.org/0000-0002-9053-2398
Alexandre ToulmayNational Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD, USA.
Tamas BallaNational Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA.

Funding

Phosphoinositide-calcium Signaling In Cell RegulationZIAHD000196 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI BALLA, TAMAS · 2009 to 2025
$26.3M
Intracellular Lipid Trafficking and Organelle BiogenesisZIADK060004 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI PRINZ, WILLIAM · 2009 to 2022
$8.5M
Intramural NIH HHS ZIA DK060004
6 · The paper itself

Abstract

Organelles compartmentalize eukaryotic cells, enhancing their ability to respond to environmental and developmental changes. One way in which organelles communicate and integrate their activities is by forming close contacts, often called 'membrane contact sites' (MCSs). Interest in MCSs has grown dramatically in the past decade as it is has become clear that they are ubiquitous and have a much broader range of critical roles in cells than was initially thought. Indeed, functions for MCSs in intracellular signalling (particularly calcium signalling, reactive oxygen species signalling and lipid signalling), autophagy, lipid metabolism, membrane dynamics, cellular stress responses and organelle trafficking and biogenesis have now been reported.

Indexed as

Lipid MetabolismSignal TransductionAnimalsAutophagosomesAutophagyBiological TransportCalcium SignalingCell MembraneEndoplasmic ReticulumEnzymesEukaryotic CellsHumansMitochondrial MembranesReactive Oxygen SpeciesStress, PhysiologicalEnzymesReactive Oxygen Species

Identifiers

PMID31732717
PMCPMC10619483

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.