Evidence map›Paper›PMID 31732683›Full record

SynthesisArchives of disease in childhood. Fetal and neonatal edition2020

Core outcomes in neonatology: development of a core outcome set for neonatal research.

James William Harrison Webbe, James M N Duffy, Elsa Afonso, Iyad Al-Muzaffar, Ginny Brunton, Anne Greenough, Nigel J Hall, Marian Knight, Jos M Latour, Caroline Lee-Davey and 7 more

Abstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Archives of disease in childhood. Fetal and neonatal edition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 120 papers, 25 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
120citing papers in PubMed, 25 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

120 citing papers in PubMed, 25 syntheses or guidelines pooled it.

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  6. Clinical rating scales for assessing pain in newborn infants.The Cochrane database of systematic reviews · 2025
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  17. Automated oxygen delivery for preterm infants with respiratory dysfunction.The Cochrane database of systematic reviews · 2023
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60 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

James William Harrison WebbeAcademic Neonatal Medicine, Imperial College London, London, UK j.webbe@imperial.ac.uk.ORCID http://orcid.org/0000-0001-8546-3212
James M N DuffyNuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, Oxfordshire, UK.
Elsa AfonsoNeonatal Unit, Rosie Hospital, Cambridge, Cambridgeshire, UK.
Iyad Al-MuzaffarThe Neonatal Unit, Royal Glamorgan Hospital, Llantrisant, Rhondda Cynon Taf, UK.
Ginny BruntonUCL Institute of Education Centre for Longitudinal Studies, London, UK.
Anne GreenoughDepartment of Women and Children's Health, School of Life Sciences, Faculty of Life Sciences and Medicine, King's College London, London, UK.ORCID http://orcid.org/0000-0002-8672-5349
Nigel J HallPaediatric Surgery, Southampton General Hospital, Southampton, UK.ORCID http://orcid.org/0000-0001-8570-9374
Marian KnightNational Perinatal Epidemiology Unit, Oxford, UK.ORCID http://orcid.org/0000-0002-1984-4575
Jos M LatourSchool of Nursing and Midwifery, Faculty of Health, Education and Society, Plymouth University, Plymouth, Devon, UK.
Caroline Lee-DaveyBliss, London, UK.
Neil MarlowInstitute for Women's Health, University College London, London, UK.ORCID http://orcid.org/0000-0001-5890-2953
Laura NoakesParent of Neonatal Patient, London, UK.
Julie NycykNeonatal Unit, Birmingham City Hospital, Birmingham, UK.
Angela Richard-LöndtParent of Neonatal Patient, London, UK.
Ben Wills-EveFormer neonatal patient, London, UK.
Neena ModiNeonatal Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0002-2093-0681
Chris GaleAcademic Neonatal Medicine, Imperial College London, London, UK.ORCID http://orcid.org/0000-0003-0707-876X

Funding

Medical Research Council MR/N008405/1
6 · The paper itself

Abstract

backgroundNeonatal research evaluates many different outcomes using multiple measures. This can prevent synthesis of trial results in meta-analyses, and selected outcomes may not be relevant to former patients, parents and health professionals.

objectiveTo define a core outcome set (COS) for research involving infants receiving neonatal care in a high-income setting.

designOutcomes reported in neonatal trials and qualitative studies were systematically reviewed. Stakeholders were recruited for a three-round international Delphi survey. A consensus meeting was held to confirm the final COS, based on the survey results.

participantsFour hundred and fourteen former patients, parents, healthcare professionals and researchers took part in the eDelphi survey; 173 completed all three rounds. Sixteen stakeholders participated in the consensus meeting.

resultsThe literature reviews identified 104 outcomes; these were included in round 1. Participants proposed 10 additional outcomes; 114 outcomes were scored in rounds 2 and 3. Round 1 scores showed different stakeholder groups prioritised contrasting outcomes. Twelve outcomes were included in the final COS: survival, sepsis, necrotising enterocolitis, brain injury on imaging, general gross motor ability, general cognitive ability, quality of life, adverse events, visual impairment/blindness, hearing impairment/deafness, retinopathy of prematurity and chronic lung disease/bronchopulmonary dysplasia. CONCLUSIONS AND RELEVANCE: A COS for clinical trials and other research studies involving infants receiving neonatal care in a high-income setting has been identified. This COS for neonatology will help standardise outcome selection in clinical trials and ensure these are relevant to those most affected by neonatal care.

Indexed as

Biomedical ResearchNeonatologyOutcome Assessment, Health CareHumansInfantevidence based medicineneonatologyoutcomes research

Identifiers

PMID31732683
PMCPMC7363790

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.