Evidence map›Paper›PMID 31732571›Full record

ArticleApplied and environmental microbiology2020

Eleni Vikeli, David A Widdick, Sibyl F D Batey, Daniel Heine, Neil A Holmes, Mervyn J Bibb, Dino J Martins, Naomi E Pierce, Matthew I Hutchings, Barrie Wilkinson

Open access · hybridAbstract read
In one paragraph

Article in Applied and environmental microbiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 36 citations in OpenAlex.

  1. Article
  2. Surfactin-ProducingFoods (Basel, Switzerland) · 2026
    Article
  3. Discovery of Coerumycin, a Cinnamycin-like Lantibiotic fromAntibiotics (Basel, Switzerland) · 2026
    Article
  4. Article
  5. Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Microorganisms · 2023
    Article
  17. Review
  18. The potential of facultative predatoryFrontiers in microbiology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 3 countries.

Eleni Vikeli *Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0003-0027-5015
David A Widdick *Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0001-9872-918X
Sibyl F D Batey *Department of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0001-6288-660X
Daniel HeineDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0002-3075-7966
Neil A HolmesSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom.ORCID 0000-0002-4979-9680
Mervyn J BibbDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom.ORCID 0000-0002-7289-6745
Dino J MartinsDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0003-1581-1642
Naomi E PierceDepartment of Organismic and Evolutionary Biology, Harvard University, Cambridge, Massachusetts, USA.ORCID 0000-0003-3366-1625
Matthew I HutchingsSchool of Biological Sciences, University of East Anglia, Norwich, United Kingdom m.hutchings@uea.ac.uk barrie.wilkinson@jic.ac.uk.ORCID 0000-0001-6628-5940
Barrie WilkinsonDepartment of Molecular Microbiology, John Innes Centre, Norwich, United Kingdom m.hutchings@uea.ac.uk barrie.wilkinson@jic.ac.uk.ORCID 0000-0001-7646-7174
John Innes Centre · GBHarvard University · USUniversity of East Anglia · GB

Funding

Biotechnology and Biological Sciences Research Council BB/L013754/1Biotechnology and Biological Sciences Research Council BB/M011216/1Biotechnology and Biological Sciences Research Council BB/P012523/1Biotechnology and Biological Sciences Research Council BB/P021506/1Biotechnology and Biological Sciences Research Council BBS/E/J/00000607Biotechnology and Biological Sciences Research Council BBS/E/J/000PR9790
6 · The paper itself

Abstract

Most clinical antibiotics are derived from actinomycete natural products discovered at least 60 years ago. However, the repeated rediscovery of known compounds led the pharmaceutical industry to largely discard microbial natural products (NPs) as a source of new chemical diversity. Recent advances in genome sequencing have revealed that these organisms have the potential to make many more NPs than previously thought. Approaches to unlock NP biosynthesis by genetic manipulation of strains, by the application of chemical genetics, or by microbial cocultivation have resulted in the identification of new antibacterial compounds. Concomitantly, intensive exploration of coevolved ecological niches, such as insect-microbe defensive symbioses, has revealed these to be a rich source of chemical novelty. Here, we report the new lanthipeptide antibiotic kyamicin, which was generated through the activation of a cryptic biosynthetic gene cluster identified by genome mining

Indexed as

Genes, BacterialAnimalsAnti-Bacterial AgentsAntsBacteriocinsFabaceaeMultigene FamilySaccharopolysporaAnti-Bacterial AgentsBacteriocinscinnamycinlanthipeptidelantibioticplant-antSaccharopolyspora

Identifiers

PMID31732571
PMCPMC6974636
OpenAlexW2984060293

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.