ArticleThe Journal of rheumatology2020
Effect of a Single Apolipoprotein L1 Gene Nephropathy Variant on the Risk of Advanced Lupus Nephritis in Brazilians.
Open access · bronzeAbstract read
In one paragraph
Article in The Journal of rheumatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
2.1field-weighted citation impact, top 13% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Apolipoprotein L1 risk genotypes and odds of lupus nephritis-associated kidney failure in systemic lupus erythematosus: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- Update on APOL1 and chronic kidney diseases in children.Pediatric nephrology (Berlin, Germany) · 2026Review
- An integrative review of APOL1 kidney disease with a focus on the Brazilian population.Clinics (Sao Paulo, Brazil) · 2026Review
- Should Nephrology Clinical Trials Account for Apolipoprotein L1 Gene Risk Status?Clinical journal of the American Society of Nephrology : CJASN · 2026Article
- Focal segmental glomerulosclerosis in a native African patient with systemic lupus erythematosus.Journal of nephrology · 2025Article
- Multiethnic prevalence of theClinical kidney journal · 2025Article
- Article
- The 330 risk loci known for systemic lupus erythematosus (SLE): a review.Frontiers in lupus · 2024Article
- Article
- Genetics of Chronic Kidney Disease in Low-Resource Settings.Seminars in nephrology · 2022Review
- Expert Perspective: An Approach to Refractory Lupus Nephritis.Arthritis & rheumatology (Hoboken, N.J.) · 2022Article
- Article
- Recipient APOL1 risk alleles associate with death-censored renal allograft survival and rejection episodes.The Journal of clinical investigation · 2021Article
- The Pathogenesis, Molecular Mechanisms, and Therapeutic Potential of the Interferon Pathway in Systemic Lupus Erythematosus and Other Autoimmune Diseases.International journal of molecular sciences · 2021Review
- APOL1 in an ethnically diverse pediatric population with nephrotic syndrome: implications in focal segmental glomerulosclerosis and other diagnoses.Pediatric nephrology (Berlin, Germany) · 2021Article
- Collapsing Focal Segmental Glomerulosclerosis in Viral Infections.Frontiers in immunology · 2021Review
- Apolipoprotein L1 risk genotypes in Ghanaian patients with systemic lupus erythematosus: a prospective cohort study.Lupus science & medicine · 2021Article
- Kidney Disease-AssociatedJournal of the American Society of Nephrology : JASN · 2020Article
Corrections and comments
- Commented on by
Authors and funding
13 authors at 2 institutions in 3 countries.
Gisele VajgelFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil. giselevajgel@hotmail.com.ORCID 0000-0002-2606-3638
Suelen Cristina LimaFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Diego Jeronimo S SantanaFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Camila B L OliveiraFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Denise Maria N CostaFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Pamela J HicksFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Maria Alina G M CavalcanteFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Carl D LangefeldFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Lucila Maria ValenteFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Sergio CrovellaFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Gianna Mastroianni KirsztajnFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Barry I FreedmanFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Paula Sandrin-GarciaFrom the Division of Nephrology, Hospital das Clinicas, Federal University of Pernambuco (UFPE); Molecular Biology Laboratory, Keizo Asami Immunopathology Laboratory (LIKA), UFPE; Division of Nephrology, Instituto de Medicina Integral Prof. Fernando Figueira (IMIP), Recife, Pernambuco, Brazil; Division of Public Health Sciences, Department of Biostatistical Sciences, and Center for Diabetes Research, and Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA; Division of Nephrology, Department of Medicine, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
Universidade Federal de Pernambuco · BRInstituto de Medicina Integral Professor Fernando Figueira · BR
Funding
Genetic Analysis of African American Hypertensive End-Stage Renal DiseaseR01DK070941 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2006 to 2015
$4.7MNatural History of MYH9-Associated NephropathyR01DK084149 · NIDDK · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI FREEDMAN, BARRY IRA · 2009 to 2012
$2.3MNIDDK NIH HHS R01 DK070941NIDDK NIH HHS R01 DK084149
Abstract
objectiveApolipoprotein L1 gene (
methodsAPOL1 RRA were genotyped in 222 healthy blood donors (controls) and 201 cases with LN from 3 outpatient clinics. Two single-nucleotide polymorphisms in the G1 (rs73885319 and rs60910145) and an indel for the G2 (rs71785313) variant were genotyped.
resultsThe frequency of
conclusionAlthough initial kidney lesions and treatment responses were similar, a single
Indexed as
Apolipoprotein L1Lupus NephritisGenetic Predisposition to DiseaseGenotypeHumansPolymorphism, Single NucleotideAPOL1 protein, humanApolipoprotein L1APOLIPOPROTEINSBIOPSYKIDNEY FAILURELUPUS NEPHRITIS
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.