ArticleMolecular cell2020
Epigenetic Regulator CoREST Controls Social Behavior in Ants.
Article in Molecular cell, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 60 citations in OpenAlex.
- Genome Evolution in Social Insects.Genome biology and evolution · 2026Review
- Regulation of reproductive and behavioral plasticity in social insects.Current opinion in insect science · 2026Review
- Convergent evolution of a conserved molecular network underlies parenting and sociality.Nature reviews. Genetics · 2026Review
- The histone code at a crossroads: history, context, and new approaches.Trends in genetics : TIG · 2026Review
- Seasonal timing in a changing world: the epigenetic link between environment and reproduction across taxa.Environmental epigenetics · 2026Article
- Neuropeptides specify and reprogram division of labor in the leafcutter ant Atta cephalotes.Cell · 2025Article
- The Fire Ant Social Chromosome Exerts a Major Influence on Genome Regulation.Molecular biology and evolution · 2025Article
- Insect circadian plasticity as a proposed target for the expression of parasite extended phenotypes.Npj biological timing and sleep · 2025Review
- Neuropeptides specify and reprogram division of labor in the leafcutter antbioRxiv : the preprint server for biology · 2024Article
- The Molecular Substrates of Insect Eusociality.Annual review of genetics · 2024Review
- A plant virus differentially alters DNA methylation in two cryptic species of a hemipteran vector.Npj viruses · 2024Article
- Phenomenon of reproductive plasticity in ants.Current opinion in insect science · 2024Review
- DNA methylation extends lifespan in the bumblebeeProceedings. Biological sciences · 2023Article
- Neuromodulators and neuroepigenetics of social behavior in ants.Annals of the New York Academy of Sciences · 2023Review
- Hormonal gatekeeping via the blood-brain barrier governs caste-specific behavior in ants.Cell · 2023Article
- Article
- Histone acetyltransferases and external demands influence task switching inBiology letters · 2023Article
- Social experience and pheromone receptor activity reprogram gene expression in sensory neurons.G3 (Bethesda, Md.) · 2023Article
- Long ant life span is maintained by a unique heat shock factor.Genes & development · 2023Article
- Histone 4 lysine 5/12 acetylation enables developmental plasticity of Pristionchus mouth form.Nature communications · 2023Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Ants acquire distinct morphological and behavioral phenotypes arising from a common genome, underscoring the importance of epigenetic regulation. In Camponotus floridanus, "Major" workers defend the colony, but can be epigenetically reprogrammed to forage for food analogously to "Minor" workers. Here, we utilize reprogramming to investigate natural behavioral specification. Reprogramming of Majors upregulates Minor-biased genes and downregulates Major-biased genes, engaging molecular pathways fundamental to foraging behavior. We discover the neuronal corepressor for element-1-silencing transcription factor (CoREST) is upregulated upon reprogramming and required for the epigenetic switch to foraging. Genome-wide profiling during reprogramming reveals CoREST represses expression of enzymes that degrade juvenile hormone (JH), a hormone elevated upon reprogramming. High CoREST, low JH-degrader expression, and high JH levels are mirrored in natural Minors, revealing parallel mechanisms of natural and reprogrammed foraging. These results unveil chromatin regulation via CoREST as central to programming of ant social behavior, with potential far-reaching implications for behavioral epigenetics.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.