Evidence map›Paper›PMID 31732298›Full record

ArticleMolecular therapy : the journal of the American Society of Gene Therapy2020

miR24-2 Promotes Malignant Progression of Human Liver Cancer Stem Cells by Enhancing Tyrosine Kinase Src Epigenetically.

Liyan Wang, Xiaonan Li, Wei Zhang, Yuxin Yang, Qiuyu Meng, Chen Wang, Xiaoru Xin, Xiaoxue Jiang, Shuting Song, Yanan Lu and 7 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular therapy : the journal of the American Society of Gene Therapy, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
0.8field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 29 citations in OpenAlex.

  1. Review
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  4. Autophagy and cancer therapy.Cancer letters · 2024
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  9. The essential roles of lncRNAs/PI3K/AKT axis in gastrointestinal tumors.Frontiers in cell and developmental biology · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Liyan WangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xiaonan LiShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Wei ZhangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yuxin YangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Qiuyu MengShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Chen WangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xiaoru XinShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xiaoxue JiangShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Shuting SongShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Yanan LuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Hu PuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Xin GuiShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Tianming LiShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China.
Jie XuSchool of Medicine, Tongji University, Shanghai 200092, China.
Jiao LiSchool of Medicine, Tongji University, Shanghai 200092, China.
Song JiaSchool of Medicine, Tongji University, Shanghai 200092, China.
Dongdong LuShanghai Putuo District People's Hospital, School of Life Science and Technology, Tongji University, Shanghai 200092, China. Electronic address: ludongdong@tongji.edu.cn.
Tongji University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

MicroRNA24-2 (miR24-2) is associated with human tumorigenesis; however, its molecular mechanisms are poorly understood. Herein, our findings demonstrate that miR24-2 promotes the proliferation ability in vitro and the tumorigenic ability in vivo in human liver cancer stem cells (hLCSCs). Mechanically, the miR24-2 targets for 3' UTR (2,627-2,648) of protein arginine methyltransferase 7 (PRMT7) inhibit the translational ability of prmt7 gene. Moreover, miR24-2 inhibits the di-/tri-methylation of histone H4 arginine 3 by reducing PRMT7 and then promotes the expression of Nanog via long noncoding RNA HULC. Notably, miR24-2 inhibits histone deacetylase HDAC3 through miR675, which promotes the acetylation of histone H4 at lysine 16. Subsequently, miR24-2 enhances the interaction between LC3 and ATG4 dependent on PI3K and triggers cellular autophagy. Strikingly, miR24-2 inhibits the degradation of pyruvate kinase M1 via autophagosome-P62 in hLCSCs. Furthermore, miR24-2 enhances the activity of Src by promoting the binding of PKM1 to the Src promoter regions in hLCSCs. In particular, our results also indicate that src gene determines the oncogenic functions of miR24-2. These results provided a valuable theoretical basis for the discovery of liver cancer therapeutic targets and diagnosis markers based on miR24-2.

Indexed as

Epigenesis, GeneticGene Expression Regulation, NeoplasticAcetylationAutophagyCarrier ProteinsCell Line, TumorDisease ProgressionHistonesHumansLiver NeoplasmsMembrane ProteinsMethylationMicroRNAsNanog Homeobox ProteinNeoplastic Stem CellsProtein-Arginine N-MethyltransferasesCarrier ProteinsHistonesMembrane ProteinsMicroRNAsMIRN24 microRNA, humanNanog Homeobox ProteinNANOG protein, humanPRMT7 protein, humanProtein-Arginine N-Methyltransferasessrc-Family KinasesThyroid Hormone-Binding ProteinsThyroid Hormonesautophagyhistone epigenetic modificationliver cancer stem cellsmiR24-2tyrosine protein kinase sarcoma gene Src

Identifiers

PMID31732298
PMCPMC7001004
OpenAlexW2982276421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.