Evidence map›Paper›PMID 31732232›Full record

ArticleAmerican journal of kidney diseases : the official journal of the National Kidney Foundation2020

Donor-Recipient Relationship and Risk of ESKD in Live Kidney Donors of Varied Racial Groups.

Abimereki D Muzaale, Allan B Massie, Fawaz Al Ammary, Macey L Henderson, Tanjala S Purnell, Courtenay M Holscher, Jacqueline Garonzik-Wang, Jayme E Locke, Jon J Snyder, Krista L Lentine and 1 more

Open access · greenAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of kidney diseases : the official journal of the National Kidney Foundation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 2 pooled it
4.4field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Examining post-donation outcomes in Hispanic/Latinx living kidney donors in the United States: A systematic review.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2022
    Pooled it
  3. Article
  4. Article
  5. Article
  6. The Living Kidney Donor Safety Study: Protocol of a Prospective Cohort Study.Canadian journal of kidney health and disease · 2022
    Article
  7. Review
  8. Review
  9. Article
  10. The first increase in live kidney donation in the United States in 15 years.American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons · 2020
    Article
  11. Apolipoprotein L1: role in the evaluation of kidney transplant donors.Current opinion in nephrology and hypertension · 2020
    Article
  12. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Abimereki D MuzaaleDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD. Electronic address: amuzaal1@jhmi.edu.
Allan B MassieDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Fawaz Al AmmaryDepartment of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
Macey L HendersonDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Acute and Chronic Care, Johns Hopkins School of Nursing, Baltimore, MD.
Tanjala S PurnellDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD.
Courtenay M HolscherDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Jacqueline Garonzik-WangDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Jayme E LockeDepartment of Surgery, University of Alabama at Birmingham, Birmingham, AL.
Jon J SnyderScientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.
Krista L LentineSaint Louis University Center for Abdominal Transplantation, St. Louis, MO.
Dorry L SegevDepartment of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD; Department of Epidemiology, Johns Hopkins School of Public Health, Baltimore, MD; Scientific Registry of Transplant Recipients, Minneapolis Medical Research Foundation, Minneapolis, MN.
Johns Hopkins Medicine · USJohns Hopkins University · USOrthopaedic Research Foundation · USSaint Louis University · USUniversity of Alabama at Birmingham · US

Funding

Long-Term Health Outcomes After Live Kidney Donation in African AmericansR01DK096008 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2013 to 2017
$3.8M
CKD Risk Prediction among Obese Living Kidney DonorsR01DK113980 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCKE, JAYME ELIZABETH · 2018 to 2022
$3.4M
Patient Oriented Research in Solid Organ TransplantationK24AI144954 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI SEGEV, DORRY L. · 2020 to 2024
$956k
Patient Oriented Research in Kidney Disease and Transplant SurgeryK24DK101828 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI SEGEV, DORRY L. · 2014 to 2018
$922k
Long-term outcomes among living kidney donors with isolated medical abnormalitiesK23DK103918 · NIDDK · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI LOCKE, JAYME ELIZABETH · 2015 to 2019
$899k
Determinants of chronic kidney disease in African-American live kidney donorsK01DK101677 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI MASSIE, ALLAN B · 2015 to 2019
$789k
Patient-Centered Strategies to Reduce Disparities in Access to Kidney TransplantationK01HS024600 · AHRQ · JOHNS HOPKINS UNIVERSITY · PI PURNELL, TANJALA · 2016 to 2020
$786k
Technological Innovations for Live Kidney Donor Follow-up Care ManagementK01DK114388 · NIDDK · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI LEVAN, MACEY LEIGH · 2017 to 2021
$720k
Trajectory of post-donation renal function in living kidney donorsF32DK109662 · NIDDK · JOHNS HOPKINS UNIVERSITY · PI HOLSCHER, COURTENAY · 2016 to 2018
$232k
AHRQ HHS K01 HS024600NIAID NIH HHS K24 AI144954NIDDK NIH HHS F32 DK109662NIDDK NIH HHS K01 DK101677NIDDK NIH HHS K01 DK114388NIDDK NIH HHS K23 DK103918NIDDK NIH HHS K24 DK101828NIDDK NIH HHS R01 DK096008NIDDK NIH HHS R01 DK113980
6 · The paper itself

Abstract

RATIONALE &

objectiveRisk factors for kidney failure are the basis of live kidney donor candidate evaluation. We quantified risk for end-stage kidney disease (ESKD) by the biological relationship of the donor to the recipient, a risk factor that is not addressed by current clinical practice guidelines. STUDY

designRetrospective cohort study. SETTING &

participantsA cohort of 143,750 US kidney donors between 1987 and 2017. EXPOSURE: Biological relationship of donor and recipient. OUTCOME: ESKD. Donors' records were linked to national dialysis and transplantation registries to ascertain development of the outcome. ANALYTIC APPROACH: Donors were observed over a median of 12 (interquartile range, 6-18; maximum, 30) years. Survival analysis methods that account for the competing risk for death were used.

resultsRisk for ESKD varied by orders of magnitude across donor-recipient relationship categories. For Asian donors, risks compared with unrelated donors were 259.4-fold greater for identical twins (95% CI, 19.5-3445.6), 4.7-fold greater for full siblings (95% CI, 0.5-41.0), 3.5-fold greater for offspring (95% CI, 0.6-39.5), 1.0 for parents, and 1.0 for half-sibling or other biological relatives. For black donors, risks were 22.5-fold greater for identical twin donors (95% CI, 4.7-107.0), 4.1-fold for full siblings (95% CI, 2.1-7.8), 2.7-fold for offspring (95% CI, 1.4-5.4), 3.1-fold for parents (95% CI, 1.4-6.8), and 1.3-fold for half-sibling or other biological relatives (95% CI, 0.5-3.3). For white donors, risks were 3.5-fold greater for identical twin donors (95% CI, 0.5-25.3), 2.0-fold for full siblings (95% CI, 1.4-2.8), 1.4-fold for offspring (95% CI, 0.9-2.3), 2.9-fold for parents (95% CI, 2.0-4.1), and 0.8-fold for half-sibling or other biological relatives (95% CI, 0.3-1.6). LIMITATIONS: Insufficient sample size in some race and relationship groups. Absence of data for family history of kidney disease for donors biologically unrelated to their recipients.

conclusionsMarked differences in risk for ESKD across types of donor-recipient relationship were observed for Asian, black, and white donors. These findings warrant further validation with more robust data to better inform clinical practice guidelines.

Indexed as

Interpersonal RelationsKidney TransplantationRegistriesAdultEthnicityFemaleFollow-Up StudiesGraft SurvivalHumansIncidenceKidney Failure, ChronicLiving DonorsMaleMiddle AgedNephrectomyRetrospective Studiesancestrybiological relationshipdonor-recipient relationshipend-stage renal disease (ESRD)family history of diseasehealth risksKidney donationkidney failureliving-related donoroffspringparentrace/ethnicityrenal transplantationrisk of ESRDsibling

Identifiers

PMID31732232
PMCPMC7042071
OpenAlexW2983648972

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.