ArticleNeurobiology of aging2020
Impaired motor skills and atypical functional connectivity of the sensorimotor system in 40- to 65-year-old adults with autism spectrum disorders.
Article in Neurobiology of aging, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Cognitive and Cerebral Aging Research in Autism: A Systematic Review on an Emerging Topic.Autism research : official journal of the International Society for Autism Research · 2025Pooled it
- Eye-hand coordination during upper limb motor tasks in individuals with or without a neurodevelopmental disorder: a systematic review.Frontiers in neurology · 2025Pooled it
- Gross motor impairment and its relation to social skills in autism spectrum disorder: A systematic review and two meta-analyses.Psychological bulletinPooled it
- Gait variability development in autistic individuals across childhood and adulthood.Research square · 2026Article
- Movement Coordination's Link with Common Ground During Dyadic Peer Discourse in Typically Developing and Autistic Speakers.Journal of autism and developmental disorders · 2026Article
- Motor Performance in Autistic Youth From Childhood Through Adolescence: Evidence for Both Sustained and Widening Group Differences.Autism research : official journal of the International Society for Autism Research · 2026Article
- Age-related differences in behavioral and brain predictors of parkinsonism in autistic adults.Frontiers in aging neuroscience · 2026Article
- An Acoustic Analysis of Speech Motor Performance in Autistic Children.Journal of speech, language, and hearing research : JSLHR · 2025Article
- Sensory-movement underpinnings of lifelong neurodivergence: getting a grip on autism.Frontiers in integrative neuroscience · 2025Article
- Autism Spectrum Disorder in adults: an integrative review about strategies for promotion and maintenance of quality of life.Sao Paulo medical journal = Revista paulista de medicina · 2025Review
- Symmetric bimanual coordination discrepancy and activities of daily living in individuals with autism spectrum disorder.International journal of developmental disabilities · 2025Article
- Structured neurological soft signs examination reveals motor coordination deficits in adults diagnosed with high-functioning autism.Scientific reports · 2024Article
- Associations between atypical intracortical myelin content and neuropsychological functions in middle to older aged adults with ASD.Brain and behavior · 2024Article
- Impaired Biological Motion Processing and Motor Skills in Adults with Autistic Traits.Journal of autism and developmental disorders · 2023Article
- Deficiency of Autism-Related Gene Dock4 Leads to Impaired Spatial Memory and Hippocampal Function in Mice at Late Middle Age.Cellular and molecular neurobiology · 2023Article
- Community-based postural control assessment in autistic individuals indicates a similar but delayed trajectory compared to neurotypical individuals.Autism research : official journal of the International Society for Autism Research · 2023Article
- From "one big clumsy mess" to "a fundamental part of my character." Autistic adults' experiences of motor coordination.PloS one · 2023Article
- Transcriptional substrates underlying functional connectivity profiles of subregions within the human sensorimotor cortex.Human brain mapping · 2022Article
- Combined Gait and Grasping in Autistic and Non-Autistic Youths.Developmental neurorehabilitation · 2022Article
- Reduced asymmetry of the hand knob area and decreased sensorimotor u-fiber connectivity in middle-aged adults with autism.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Impairments in fine and gross motor function, coordination, and balance in early development are common in autism spectrum disorders (ASDs). It is unclear whether these deficits persist into adulthood and whether they may be exacerbated by additional motor problems that often emerge in typical aging. We assessed motor skills and used resting-state functional magnetic resonance imaging to study intrinsic functional connectivity of the sensorimotor network in 40- to 65-year-old adults with ASDs (n = 17) and typically developing matched adults (n = 19). Adults with ASDs scored significantly lower on assessments of motor skills compared with an age-matched group of typical control adults. In addition, functional connectivity of the sensorimotor system was reduced and the pattern of connectivity was more heterogeneous in adults with ASDs. A negative correlation between functional connectivity of the motor system and motor skills, however, was only found in the typical control group. Findings suggest behavioral impairment and atypical brain organization of the motor system in middle-age adults with ASDs, accompanied by pronounced heterogeneity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.