ArticleNeurobiology of aging2019
What are the later life contributions to reserve, resilience, and compensation?
Article in Neurobiology of aging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed.
- Trial
- Does neurodevelopmental load predict cognitive flexibility?Schizophrenia research. Cognition · 2026Article
- APOE4 carriers resistant to cognitive decline show unique relationships between cerebrovascular response to exercise and dual-task cognitive-balance performance.Frontiers in neuroscience · 2026Article
- Cohort profile: the Resilient Minds national study of mental health and cognitive resilience in community dwelling adults aged 18 to 93.Frontiers in digital health · 2026Article
- Analysis of Event-related Potential Dynamics Reveals Lavender Aroma Modulates Cognitive Flexibility: An Electroencephalography Investigation Based on Task Switching Paradigms.Journal of medical signals and sensors · 2026Article
- Psychological well-being in cognitively intact adults aged 80+: Findings from the SuperAging Research Initiative.Frontiers in psychology · 2026Article
- Association Between Physical Activity and the Risk of Dementia Among Patients With Depression: A Nationwide Cohort Study.Psychiatry investigation · 2025Article
- APOE4 carriers resistant to cognitive decline show unique relationships between cerebrovascular response to exercise and dual-task cognitive-balance performance.bioRxiv : the preprint server for biology · 2025Article
- How to Improve Cognitive Flexibility: Evidence From Noninvasive Neuromodulation Techniques.CNS neuroscience & therapeutics · 2025Review
- Influence of daily life and health profile in subtle cognitive decline of women residing in Spanish religious communities: DeCo religious orders study.Frontiers in public health · 2024Observational
- Cognitive flexibility: neurobehavioral correlates of changing one's mind.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Can we promote cognitive resilience in late-life depression?International psychogeriatrics · 2023Article
- Broadening the identification of superior cognition in older age.Arquivos de neuro-psiquiatria · 2023Article
- Cognitive interventions for memory and psychological well-being in aging and dementias.Frontiers in psychology · 2023Review
- Social isolation reinforces aging-related behavioral inflexibility by promoting neuronal necroptosis in basolateral amygdala.Molecular psychiatry · 2022Article
- Elevated Dopamine Synthesis as a Mechanism of Cognitive Resilience in Aging.Cerebral cortex (New York, N.Y. : 1991) · 2022Article
- Markers of kidney function, genetic variation related to cognitive function, and cognitive performance in the UK Biobank.BMC nephrology · 2022Article
- Simulated visual hallucinations in virtual reality enhance cognitive flexibility.Scientific reports · 2022Article
- The Nuance of Bilingualism as a Reserve Contributor: Conveying Research to the Broader Neuroscience Community.Frontiers in psychology · 2022Article
- Factors Affecting Rapid Cognitive Decline in Patients with Alzheimer's Disease: A Longitudinal Follow-Up Study.International journal of environmental research and public health · 2021Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Many studies have shown that early-life experiences can contribute to later life cognitive reserve and resilience. However, there is evidence to suggest that later life experiences and lifestyle choices can also play a vital role in the brain's ability to respond to and compensate for neural insults associated with aging. Engaging in a diversity of behaviorally, socially, and cognitively rich activities may forge new neural pathways that can perhaps provide greater flexibility in confronting the challenges associated with accumulating brain pathology. Studies of cognitively normal individuals with pathology and of individuals who have aged exceptionally well may provide insights that are generalizable to the overall elderly population.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.