Evidence map›Paper›PMID 31731760›Full record

ArticleCells2019

CCN2 Mediates S1P-Induced Upregulation of COX2 Expression in Human Granulosa-Lutein Cells.

Liao-Liao Hu, Hsun-Ming Chang, Yuyin Yi, Yingtao Liu, Elizabeth L Taylor, Li-Ping Zheng, Peter C K Leung

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cells, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.2field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Liao-Liao HuJiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.
Hsun-Ming ChangDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6H3V5, Canada.
Yuyin YiDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6H3V5, Canada.
Yingtao LiuDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6H3V5, Canada.
Elizabeth L TaylorDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6H3V5, Canada.
Li-Ping ZhengJiangxi Medical College, Nanchang University, Nanchang, Jiangxi 330031, China.
Peter C K LeungDepartment of Obstetrics and Gynaecology, BC Children's Hospital Research Institute, University of British Columbia, Vancouver, BC V6H3V5, Canada.
University of British Columbia · CANanchang University · CN

Funding

CIHR 143317
6 · The paper itself

Abstract

CCN1 and CCN2 are members of the CCN family and play essential roles in the regulation of multiple female reproductive functions, including ovulation. Cyclooxygenase-2 (COX2) is a critical mediator of ovulation and can be induced by sphingosine-1-phosphate (S1P) through the S1P

Indexed as

Cell Cycle ProteinsCell NucleusCells, CulturedConnective Tissue Growth FactorCyclooxygenase 2Cysteine-Rich Protein 61DinoprostoneDose-Response Relationship, DrugFemaleGene Expression RegulationHumansLuteal CellsLysophospholipidsSignal TransductionSphingosineSphingosine-1-Phosphate ReceptorsCCN1 protein, humanCCN2 protein, humanCell Cycle ProteinsConnective Tissue Growth FactorCyclooxygenase 2Cysteine-Rich Protein 61DinoprostoneLysophospholipidsPTGS2 protein, humanSphingosinesphingosine 1-phosphateSphingosine-1-Phosphate ReceptorsTranscription FactorsYY1AP1 protein, humanCCN2COX2human granulosa cellPGE2S1PS1P1

Identifiers

PMID31731760
PMCPMC6912539
OpenAlexW2984760335

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.