Evidence map›Paper›PMID 31731755›Full record

ArticleMolecules (Basel, Switzerland)2019

Warfarin-Capped Gold Nanoparticles: Synthesis, Cytotoxicity, and Cellular Uptake.

Loredana Florina Leopold, Dumitriţa Rugină, Ioana Oprea, Zorița Diaconeasa, Nicolae Leopold, Maria Suciu, Vasile Coman, Dan Cristian Vodnar, Adela Pintea, Cristina Coman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Loredana Florina LeopoldFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.
Dumitriţa RuginăFaculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.
Ioana OpreaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.
Zorița DiaconeasaFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0002-5325-3859
Nicolae LeopoldFaculty of Physics, Babeș-Bolyai University, Kogălniceanu 1, 400084 Cluj-Napoca, Romania.ORCID 0000-0002-2174-8064
Maria SuciuElectron Microscopy Center, Faculty of Biology and Geology, Babeș-Bolyai University, Clinicilor 5-7, 400006 Cluj-Napoca, Romania.
Vasile ComanInstitute of Life Sciences, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0001-8685-3394
Dan Cristian VodnarFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0001-5407-8071
Adela PinteaFaculty of Veterinary Medicine, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.
Cristina ComanFaculty of Food Science and Technology, University of Agricultural Sciences and Veterinary Medicine, Mănăștur 3-5, 400372 Cluj-Napoca, Romania.ORCID 0000-0002-7617-3763
University of Agricultural Sciences and Veterinary Medicine of Cluj-Napoca · ROBabeș-Bolyai University · RO

Funding

Unitatea Executiva pentru Finantarea Invatamantului Superior, a Cercetarii, Dezvoltarii si Inovarii PN-III-P1-1.1-TE-2016-1907; (PFE)-37/2018-2020
6 · The paper itself

Abstract

Currently, research studies on nanoparticle cytotoxicity, uptake or internalization into the body's cells are of great interest for the improvement of diagnostic and therapeutic applications. We report here the synthesis and characterization of very stable novel warfarin-capped gold nanoparticles with an average diameter of 54 ± 10 nm which were prepared using sodium warfarin as a reducing agent. The nanoparticles were tested in terms of cytotoxicity and cellular internalization in vitro on two cell lines: normal lung fibroblast HFL-1 and human retinal pigment epithelial D407 cells. Our results showed that the normal lung fibroblast HFL-1 cells were more sensitive to the nanoparticle treatment compared to the human retinal pigment epithelial D407 cells. Moreover, any signs of potential cytotoxicity occurred during the first 24 h of treatment, the cellular viability remaining largely unchanged for longer exposure times. Transmission electron microscopy and dark field hyperspectral imaging revealed that the nanoparticles were effectively delivered and released to the HFL-1 and D407 cells' cytoplasm. Our results provide valuable information to further investigate sodium warfarin-capped gold nanoparticles for possible biological applications.

Indexed as

GoldWarfarinCell LineCytoplasmFibroblastsHumansMetal NanoparticlesRetinal Pigment EpitheliumGoldWarfarinD407 cellsgold nanoparticlesHFL-1 cellsinternalization

Identifiers

PMID31731755
PMCPMC6891392
OpenAlexW2987924969

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.