ArticleInternational journal of molecular sciences2019
Adiponectin Reverses the Hypothalamic Microglial Inflammation during Short-Term Exposure to Fat-Rich Diet.
Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 24 citations in OpenAlex.
- Adipose Tissue-Central Nervous System Axis in Obesity: Molecular Mechanisms, Inflammation, and Nutritional and Technological Implications.Metabolites · 2026Review
- Redefining the timeline: a three-phase framework of hypothalamic microinflammation in metabolic disease.Reviews in endocrine & metabolic disorders · 2026Review
- A Sensitive Reporter Mouse Model to Study Adipocyte-Derived Extracellular Vesicles In Vivo.Journal of extracellular vesicles · 2026Article
- Microglia as candidate links between hormonal signals and neuronal circuits in polycystic ovary syndrome: evidence gaps and a research agenda.Frontiers in endocrinology · 2026Review
- New perspectives on polycystic ovary syndrome: hypothalamic-sympathetic-adipose tissue interaction.Journal of ovarian research · 2025Review
- Article
- Microglia in Central Control of Metabolism.Physiology (Bethesda, Md.) · 2024Review
- Excessive Pregestational Weight and Maternal Obstetric Complications: The Role of Adipokines.International journal of molecular sciences · 2023Review
- Fructose Diet-Associated Molecular Alterations in Hypothalamus of Adolescent Rats: A Proteomic Approach.Nutrients · 2023Article
- Metabolic factors in the regulation of hypothalamic innate immune responses in obesity.Experimental & molecular medicine · 2022Review
- Adiponectin Levels Are Associated with White Matter Lesions (WMLs) and Cognitive Impairment.BioMed research international · 2022Article
- The Impact of Obesity on Microglial Function: Immune, Metabolic and Endocrine Perspectives.Cells · 2021Review
- Adiponectin Controls Nutrient Availability in Hypothalamic Astrocytes.International journal of molecular sciences · 2021Article
- Adiponectin in Chronic Kidney Disease.International journal of molecular sciences · 2020Review
- Obesity induced by estrogen deficiency is associated with hypothalamic inflammation.Biochemistry and biophysics reports · 2020Article
- Review
- Editorial of Special Issue "Adipokines 2.0".International journal of molecular sciences · 2020Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Adiponectin, an adipokine derived from the adipose tissue, manifests anti-inflammatory effects in the metabolically active organs and is, therefore, beneficial in various metabolic diseases associated with inflammation. However, the role of adiponectin in alleviating the hypothalamic inflammation connected to the pathogenesis of obesity has not yet been clearly interrogated. Here, we identified that the systemic administration of adiponectin suppresses the activation of microglia and thereby reverses the hypothalamic inflammation during short-term exposure to a high-fat diet. Additionally, we show that adiponectin induces anti-inflammatory effects in the microglial cell line subjected to an exogenous treatment with a saturated free fatty acid. In conclusion, the current study suggests that adiponectin suppresses the saturated free fatty acid-triggered the hypothalamic inflammation by modulating the microglial activation and thus maintains energy homeostasis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.