Evidence map›Paper›PMID 31731683›Full record

SynthesisNutrients2019

Antimicrobial, Antioxidant, and Immunomodulatory Properties of Essential Oils: A Systematic Review.

Magdalena Valdivieso-Ugarte, Carolina Gomez-Llorente, Julio Plaza-Díaz, Ángel Gil

Registry-linked trialOpen access · goldAbstract readSystematic Review
In one paragraph

Synthesis in Nutrients, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05164692 (Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Respiratory Syncytial Virus), which is not on this map. Cited by 145 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
145citing papers in PubMed, 1 pooled it
29.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05164692 nacompletednot on this mapstarted 2020, after this paper: background citation

Application of LiveSpo Navax in Treatment of Acute Respiratory Disease in Children Infected With Respiratory Syncytial Virus

TypeinterventionalSponsorNational Children's Hospital, VietnamRan2020 to 2021Enrolled100ConditionsAcute Respiratory Tract InfectionsArmsLiveSpo Navax, 0.9% NaCl physiological saline
3 · Its place in the literature

Who cites it

145 citing papers in PubMed, 1 synthesis or guideline pooled it, 354 citations in OpenAlex.

  1. Pooled it
  2. Ameliorative effects ofMolecular medicine reports · 2026
    Article
  3. Article
  4. Article
  5. Review
  6. Antibiotics (Basel, Switzerland) · 2026
    Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Relaxation effects of Shikuwasa (Contemporary clinical trials communications · 2026
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Article

85 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Magdalena Valdivieso-UgarteInstitute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain.
Carolina Gomez-LlorenteInstitute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain.ORCID 0000-0003-3948-1473
Julio Plaza-DíazInstitute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain.ORCID 0000-0002-5171-9408
Ángel GilInstitute of Nutrition and Food Technology "José Mataix", Center of Biomedical Research, University of Granada, Avda. del Conocimiento s/n. 18016 Armilla, Granada, Spain.ORCID 0000-0001-7663-0939
Universidad de Granada · ES

Funding

Part of the research currently in progress in the authors' laboratory is funded by the company PAYMSA, S. A 4501
6 · The paper itself

Abstract

Essential oils (EOs) are a mixture of natural, volatile, and aromatic compounds obtained from plants. In recent years, several studies have shown that some of their benefits can be attributed to their antimicrobial, antioxidant, anti-inflammatory, and also immunomodulatory properties. Therefore, EOs have been proposed as a natural alternative to antibiotics or for use in combination with antibiotics against multidrug-resistant bacteria in animal feed and food preservation. Most of the results come from in vitro and in vivo studies; however, very little is known about their use in clinical studies. A systematic and comprehensive literature search was conducted in PubMed, Embase

Indexed as

AnimalsAnti-Infective AgentsAntioxidantsFood PreservationHumansImmunologic FactorsOils, VolatileAnti-Infective AgentsAntioxidantsImmunologic FactorsOils, Volatileantimicrobialantioxidantbiofilmessential oilsfood preservationimmunomodulatoryvolatile oils

Identifiers

PMID31731683
PMCPMC6893664
OpenAlexW2986254559

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.