Evidence map›Paper›PMID 31731670›Full record

ArticleInternational journal of molecular sciences2019

Hepatic microRNA Expression by PGC-1α and PGC-1β in the Mouse.

Elena Piccinin, Maria Arconzo, Giusi Graziano, Michele Vacca, Claudia Peres, Elena Bellafante, Gaetano Villani, Antonio Moschetta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Elena PiccininDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0002-6514-2689
Maria ArconzoINBB, National Institute for Biostuctures and Biosystems, 00136 Rome, Italy.
Giusi GrazianoINBB, National Institute for Biostuctures and Biosystems, 00136 Rome, Italy.
Michele VaccaMetabolic Research Laboratories, Wellcome Trust-MRC Institute of Metabolic Science, Box 289, Addenbrooke's Hospital, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1973-224X
Claudia PeresINBB, National Institute for Biostuctures and Biosystems, 00136 Rome, Italy.
Elena BellafanteFondazione Mario Negri Sud, Santa Maria Imbaro, 66030 Chieti, Italy.
Gaetano VillaniDepartment of Basic Medical Sciences, Neurosciences and Sense Organs, "Aldo Moro" University of Bari, 70124 Bari, Italy.
Antonio MoschettaDepartment of Interdisciplinary Medicine, University of Bari "Aldo Moro", Piazza Giulio Cesare 11, 70124 Bari, Italy.ORCID 0000-0003-2123-6074
Istituto Nazionale Biostrutture e Biosistemi · ITUniversity of Bari Aldo Moro · ITMario Negri Sud Foundation · ITWellcome/MRC Institute of Metabolic Science · GB

Funding

Associazione Italiana per la Ricerca sul Cancro IG 18987Interreg Interreg V-A Greece-Italy 2014-2020 MIS 500362Joint Programming Initiative A healthy diet for a healthy life JPI-EU FATMALMinistero dell'Istruzione, dell'Università e della Ricerca PRIN2017J3E2W2_002
6 · The paper itself

Abstract

The fine-tuning of liver metabolism is essential to maintain the whole-body homeostasis and to prevent the onset of diseases. The peroxisome proliferator-activated receptor-γ coactivators (PGC-1s) are transcriptional key players of liver metabolism, able to regulate mitochondrial function, gluconeogenesis and lipid metabolism. Their activity is accurately modulated by post-translational modifications. Here, we showed that specific PGC-1s expression can lead to the upregulation of different microRNAs widely implicated in liver physiology and diseases development and progression, thus offering a new layer of complexity in the control of hepatic metabolism.

Indexed as

AnimalsFemaleLiverLiver DiseasesMiceMicroRNAsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaReal-Time Polymerase Chain ReactionMicroRNAsPeroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alphaPpargc1a protein, mousecoactivatorsliver diseasesliver metabolismmicroRNAPGC-1

Identifiers

PMID31731670
PMCPMC6888418
OpenAlexW2983224697

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.