Evidence map›Paper›PMID 31731645›Full record

ReviewInternational journal of molecular sciences2019

Melanoma and Vitiligo: In Good Company.

Cristina Maria Failla, Maria Luigia Carbone, Cristina Fortes, Gianluca Pagnanelli, Stefania D'Atri

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 63 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Cristina Maria FaillaExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0001-5991-8914
Maria Luigia CarboneExperimental Immunology Laboratory, IDI-IRCCS, 00167 Rome, Italy.ORCID 0000-0002-3350-1210
Cristina FortesEpidemiology Unit, IDI-IRCCS, 00167 Rome, Italy.
Gianluca Pagnanelli1st Dermatology Division, IDI-IRCCS, 00167 Rome, Italy.
Stefania D'AtriMolecular Oncology Laboratory, IDI-IRCCS, 00167 Rome, Italy.
Istituti di Ricovero e Cura a Carattere Scientifico · ITIstituto Dermopatico dell'Immacolata · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG 2015 - ID. 17585Fondazione Umberto Veronesi Post-Doctoral Fellowship 2018Italian Ministry of Health Ricerca Corrente
6 · The paper itself

Abstract

Cutaneous melanoma represents the most aggressive form of skin cancer, whereas vitiligo is an autoimmune disorder that leads to progressive destruction of skin melanocytes. However, vitiligo has been associated with cutaneous melanoma since the 1970s. Most of the antigens recognized by the immune system are expressed by both melanoma cells and normal melanocytes, explaining why the autoimmune response against melanocytes that led to vitiligo could be also present in melanoma patients. Leukoderma has been also observed as a side effect of melanoma immunotherapy and has always been associated with a favorable prognosis. In this review, we discuss several characteristics of the immune system responses shared by melanoma and vitiligo patients, as well as the significance of occurrence of leukoderma during immunotherapy, with special attention to check-point inhibitors.

Indexed as

Autoimmune DiseasesHumansImmunotherapyMelanomaPrognosisVitiligoautoimmunitymelanomaprognostic markers

Identifiers

PMID31731645
PMCPMC6888090
OpenAlexW2986928599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.