Evidence map›Paper›PMID 31731602›Full record

ArticleInternational journal of molecular sciences2019

Low Molecular Seleno-Aminopolysaccharides Protect the Intestinal Mucosal Barrier of Rats under Weaning Stress.

Zheng-Shun Wen, Ming Du, Zhen Tang, Tian-Yi Zhou, Zhong-Shan Zhang, Hou-Hui Song, Xing-Wei Xiang, Xin-Yan Han

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 35 citations in OpenAlex.

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  9. Mechanism of Nrf2 in the treatment of ulcerative colitis via regulating macrophage polarization.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023
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  11. The Water Extract ofAntioxidants (Basel, Switzerland) · 2023
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  17. Article
  18. Article
  19. Anti-Inflammatory Effects ofMarine drugs · 2021
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Zheng-Shun WenZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China.
Ming DuZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China.
Zhen TangZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China.
Tian-Yi ZhouZhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products, School of Food Science and Pharmaceutics, Zhejiang Ocean University, Zhoushan 316022, China.
Zhong-Shan ZhangKey Laboratory of Vector Biology and Pathogen Control of Zhejiang Province, Huzhou University, Huzhou 313000, China.
Hou-Hui SongCollege of Animal Science and Technology of Zhejiang A&F University, Key Laboratory of Applied Technology on Green-Eco-Healthy Animal Husbandry of Zhejiang Province, Zhejiang Provincial Engineering Laboratory for Animal Health Inspection and Internet Technology, China-Australian Joint Laboratory for Animal Health Big Data Analytics, Hangzhou 311300, China.
Xing-Wei XiangDepartment of Food Science and Engineering, Zhejiang University of Technology, Hangzhou 310014, China.
Xin-Yan HanThe Key Laboratory of Molecular Animal Nutrition, Ministry of Education. Key Laboratory of Animal Nutrition and Feed Science in East China, Ministry of Agriculture, College of Animal Science, Zhejiang University, 866 Yuhangtang Road, Hangzhou 310058, China.
Zhejiang Ocean University · CNHuzhou University · CNMinistry of Agriculture and Rural Affairs · CNZhejiang University of Technology · CN

Funding

Fundamental Research Funds for Zhejiang Provincial Universities 2019JZ00010National Natural Science Foundation of China 31301982Zhejiang Provincial Key Research and Development Project of China 2019C02076Zhejiang Provincial Natural Science Foundation of China LY17C170001; LY18D060001Zhoushan Science and Technology Project of China 2018C21019
6 · The paper itself

Abstract

Low molecular seleno-aminopolysaccharide (LSA) was synthesized with sodium selenite and low molecular aminopolysaccharide (LA), which is an organic selenium compound. This study is aimed to investigate the protective effect of LSA on the intestinal mucosal barrier in weaning stress rats by detecting the intestinal tissue morphology and function, mucosal thickness and permeability, the structure of MUC2, antioxidant index, the expression level of intracellular transcription factor NF-E2-related factor 2 (Nrf2), and its related factors. The results showed that LSA significantly increased the height of intestinal villi (

Indexed as

AnimalsAntioxidantsBlotting, WesternIntestinal MucosaMaleOxidative StressPolysaccharidesRatsRats, Sprague-DawleyReverse Transcriptase Polymerase Chain ReactionSeleniumSignal TransductionWeaningAntioxidantsPolysaccharidesSeleniumintestinal mucosalow molecular seleno-aminopolysaccharideMUC2Nrf2-Keap1 pathway

Identifiers

PMID31731602
PMCPMC6888692
OpenAlexW2983832506

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.