Evidence map›Paper›PMID 31731437›Full record

ArticleMolecules (Basel, Switzerland)2019

Catalyst-Free Synthesis of Polysubstituted 5-Acylamino-1,3-Thiazoles via Hantzsch Cyclization of α-Chloroglycinates.

Mara Tomassetti, Gabriele Lupidi, Pamela Piermattei, Federico V Rossi, Samuele Lillini, Gianluca Bianchini, Andrea Aramini, Marco A Ciufolini, Enrico Marcantoni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Modern Strategies for Heterocycle Synthesis.Molecules (Basel, Switzerland) · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mara TomassettiDompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
Gabriele LupidiSchool of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
Pamela PiermatteiSchool of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
Federico V RossiSchool of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.
Samuele LilliniDompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
Gianluca BianchiniDompé Farmaceutici S.p.A., Via Campo di Pile, L'Aquila 67100, Italy.
Andrea AraminiDompé Farmaceutici S.p.A., Via Pietro Castellino, Napoli 80131, Italy.
Marco A CiufoliniDepartment of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC V6T 1Z1, Canada.
Enrico MarcantoniSchool of Science and Technology, Chemistry Division, University of Camerino, Camerino 62032, Italy.ORCID 0000-0002-8686-3987

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A catalyst-free heterocyclization reaction of α-chloroglycinates with thiobenzamides or thioureas leading to 2,4-disubstituted-5-acylamino-1,3-thiazoles has been developed. The methodology provides straightforward access to valuable building blocks for pharmaceutically relevant compounds.

Indexed as

CyclizationMolecular StructureCatalysisThiazolesThiazoles5-acylamino-1,3-thiazolesHantzsch reactionα-chloroglycinates

Identifiers

PMID31731437
PMCPMC6864457

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.