Evidence map›Paper›PMID 31731423›Full record

ReviewDiagnostics (Basel, Switzerland)2019

Pediatric Sarcoidosis: A Review with Emphasis on Early Onset and High-Risk Sarcoidosis and Diagnostic Challenges.

Brian Chiu, Jackie Chan, Sumit Das, Zainab Alshamma, Consolato Sergi

Open access · goldAbstract readReview
In one paragraph

Review in Diagnostics (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Why so low? An unusual case of myositis in a child.Pediatric rheumatology online journal · 2023
    Article
  8. Review
  9. Article
  10. Article
  11. Pulmonary granulomatosis of genetic origin.European respiratory review : an official journal of the European Respiratory Society · 2021
    Review
  12. Article
  13. Distinguishing Blau Syndrome from Systemic Sarcoidosis.Current allergy and asthma reports · 2021
    Review
  14. Article
  15. Review
  16. Pediatrics: An Evolving Concept for the 21st Century.Diagnostics (Basel, Switzerland) · 2019
    Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Brian ChiuDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.
Jackie ChanDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.
Sumit DasDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.
Zainab AlshammaDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.
Consolato SergiDepartment of Laboratory Medicine and Pathology, University of Alberta, Edmonton, Alberta T6G 2B7, Canada.ORCID 0000-0002-2779-7879
University of Alberta · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sarcoidosis is a non-necrotizing granulomatous inflammatory syndrome with multisystemic manifestations. We performed a systematic review of sarcoidosis in the pediatric population with particular emphases on early onset sarcoidosis, high-risk sarcoidosis, and newly reported or unusual sarcoid-related diseases. Blau Syndrome and early onset sarcoidosis/ BS-EOS are seen in children younger than five years old presenting with extra-thoracic manifestations but usually without lymphadenopathy and/or pulmonary involvement. The prevalence of high-risk sarcoidosis is very low in children and is further limited by the difficulty of diagnosis in symptomatic children and underdiagnosis in subclinical or asymptomatic patients. Reports of sarcoidal syndromes in users of E-cigarette/marijuana/other flavorings and their induction in cancer immunotherapies are of interests and may be challenging to differentiate from metastatic malignancy. The diagnostic considerations in pediatric sarcoidosis are to support a compatible clinicoradiographic presentation and the pathologic findings of non-necrotizing granulomas by ruling out granulomas of infective etiology. There is no absolutely reliable diagnostic test for sarcoidosis at present. The use of endoscopic bronchial ultrasound (EBUS) and transbronchial fine needle aspiration (TBNA) sampling of intrathoracic lymph nodes and lung, and for superficially accessible lesions, with cytopathological assessment and pathological confirmations provide fair diagnostic yield and excellent patient safety profile in children.

Indexed as

Blau syndromediagnosticsearly-onset sarcoidosishigh-risk sarcoidosisPaediatric sarcoidosis

Identifiers

PMID31731423
PMCPMC6963233
OpenAlexW2981721262

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.