ArticleJournal of clinical medicine2019
Delayed Intracranial Hemorrhage in Patients with Head Trauma and Antithrombotic Therapy.
Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 2 of them syntheses that pooled it.
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Who cites it
14 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Incidence of delayed bleeding in patients on antiplatelet therapy after mild traumatic brain injury: a systematic review and meta-analysis.Scandinavian journal of trauma, resuscitation and emergency medicine · 2021Pooled it
- Delayed Intracranial Hemorrhage after Blunt Head Trauma while on Direct Oral Anticoagulant: Systematic Review and Meta-Analysis.Journal of the American College of Surgeons · 2021Pooled it
- Regional differences in the management of patients with mild traumatic brain injury and antithrombotic therapy-an Austrian survey.Archives of orthopaedic and trauma surgery · 2026Article
- Impact of Different DOACs on Complications of TBI After Low-Energy Trauma.Journal of clinical medicine · 2025Article
- Delayed-Onset Hematomas Following Mohs Surgery in Patients Taking a Direct Oral Anticoagulant.Cureus · 2025Article
- Incidence and outcomes of delayed intracranial hemorrhage: a population-based cohort study.Scientific reports · 2024Article
- Traumatic Brain Injury in Patients under Anticoagulant Therapy: Review of Management in Emergency Department.Journal of clinical medicine · 2024Review
- Impact of antithrombotic therapy on acute and delayed intracranial haemorrhage and evaluation of the need of short-term hospitalisation based on CT findings after mild traumatic brain injury: experience from an oral and maxillofacial surgery unit.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2024Observational
- Justification of Indication for Cranial CT Imaging after Mild Traumatic Brain Injury According to the Current National Guidelines.Diagnostics (Basel, Switzerland) · 2023Article
- Clinical Indicators for Primary Cranial CT Imaging after Mild Traumatic Brain Injury-A Retrospective Analysis.Journal of clinical medicine · 2023Article
- Management of Traumatic Brain Injury in Patients with DOAC Therapy-Are the "New" Oral Anticoagulants Really Safer?Journal of clinical medicine · 2022Article
- Does Antithrombotic Therapy Affect Outcomes in Major Trauma Patients? A Retrospective Cohort Study from a Tertiary Trauma Centre.Journal of clinical medicine · 2022Article
- Patients with Prior Craniectomy or Craniotomy Have No Increased Risk of Acute Hemorrhage after Mild Traumatic Brain Injury.International journal of environmental research and public health · 2022Article
- Acute and Delayed Intracranial Hemorrhage in Head-Injured Patients on Warfarin versus Direct Oral Anticoagulant Therapy.Journal of emergencies, trauma, and shockArticle
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDelayed intracranial hemorrhage can occur up to several weeks after head trauma and was reported more frequently in patients with antithrombotic therapy. Due to the risk of delayed intracranial hemorrhage, some hospitals follow extensive observation and cranial computed tomography (CT) protocols for patients with head trauma, while others discharge asymptomatic patients after negative CT.
methodsWe retrospectively analyzed data on patients with head trauma and antithrombotic therapy without pathologies on their initial CT. During the observation period, we followed a protocol of routine repeat CT before discharge for patients using vitamin K antagonists, clopidogrel or direct oral anticoagulants.
results793 patients fulfilled the inclusion criteria. Acetylsalicylic acid (ASA) was the most common antithrombotic therapy (46.4%), followed by vitamin K antagonists (VKA) (32.2%) and Clopidogrel (10.8%). We observed 11 delayed hemorrhages (1.2%) in total. The group of 390 patients receiving routine repeat CT showed nine delayed hemorrhages (2.3%). VKA were used in 6 of these 11 patients. One patient needed an urgent decompressive craniectomy while the other patients were discharged after an extended observation period. The patient requiring surgical intervention due to delayed hemorrhage showed neurological deterioration during the observation period.
conclusionsRoutine repeat CT scans without neurological deterioration are not necessary if patients are observed in a clinical setting. Patients using ASA as single antithrombotic therapy do not require in-hospital observation after a negative CT scan.
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