ArticleJournal of neural engineering2020
Open source silicon microprobes for high throughput neural recording.
Article in Journal of neural engineering, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 64 papers.
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64 citing papers in PubMed.
- Midline thalamic neurons show early hypersynchrony during absence seizures in mouse models.iScience · 2026Article
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- Sleep lowers waking theta frequency in the rat hippocampus.Cell reports · 2026Article
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.Science advances · 2026Article
- Novelty, Ecological Relevance, and Sexual Receptivity Modulate Neuronal Interactions between the Amygdala and Hippocampus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Multi-scale imaging and recording of in-vivo neural activity.BMB reports · 2026Review
- Visual Motion Processing in The Tree Shrew Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Robust minimally-invasive microfabricated stainless steel neural interfaces for high resolution recording.Nature communications · 2026Article
- Synergistic Geniculate and Cortical Dynamics Facilitate a Decorrelated Spatial Frequency Code in the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Neurodatascience: Past, Present, and Future.Data science in science · 2026Article
- Complementary cortical and striatal encoding of locomotor preparation and performance.iScience · 2025Article
- Learning dynamically regulates stimulus discrimination of ventral striatal D1 receptor expressing neurons.bioRxiv : the preprint server for biology · 2025Article
- Article
- Model Predictive Control on the Neural Manifold.Neural computation · 2025Article
- Chronic Probing of Deep Brain Neuronal Activity Using Nanofibrous Smart Conducting Hydrogel-Based Brain-Machine Interface Probes.Small science · 2025Article
- DREDge: robust motion correction for high-density extracellular recordings across species.Nature methods · 2025Article
- Review
- Probabilistically constrained vector summation of motion direction in the mouse superior colliculus.Current biology : CB · 2025Article
- Tonic and burst-like locus coeruleus stimulation distinctly shift network activity across the cortical hierarchy.Nature neuroscience · 2024Article
- Acute Single-Unit Multi-Electrode Recordings from the Brainstem of Head-Fixed Mice.Journal of visualized experiments : JoVE · 2024Article
4 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
objectiveMicrofabricated multielectrode arrays are widely used for high throughput recording of extracellular neural activity, which is transforming our understanding of brain function in health and disease. Currently there is a plethora of electrode-based tools being developed at higher education and research institutions. However, taking such tools from the initial research and development phase to widespread adoption by the neuroscience community is often hindered by several obstacles. The objective of this work is to describe the development, application, and open dissemination of silicon microprobes for recording neural activity in vivo. APPROACH: We propose an open source dissemination platform as an alternative to commercialization. This framework promotes recording tools that are openly and inexpensively available to the community. The silicon microprobes are designed in house, but the fabrication and assembly processes are carried out by third party companies. This enables mass production, a key requirement for large-scale dissemination. MAIN
resultsWe demonstrate the operation of silicon microprobes containing up to 256 electrodes in conjunction with optical fibers for optogenetic manipulations or fiber photometry. These data provide new insights about the relationship between calcium activity and neural spiking activity. We also describe the current state of dissemination of these tools. A file repository of resources related to designing, using, and sharing these tools is maintained online. SIGNIFICANCE: This paper is likely to be a valuable resource for both current and prospective users, as well as developers of silicon microprobes. Based on their extensive usage by a number of labs including ours, these tools present a promising alternative to other types of electrode-based technologies aimed at high throughput recording in head-fixed animals. This work also demonstrates the importance of validating fiber photometry measurements with simultaneous electrophysiological recordings.
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