Evidence map›Paper›PMID 31731260›Full record

ArticleParkinsonism & related disorders2019

Cognitive associations with comprehensive gait and static balance measures in Parkinson's disease.

Rosie Morris, Douglas N Martini, Katrijn Smulders, Valerie E Kelly, Cyrus P Zabetian, Kathleen Poston, Amie Hiller, Kathryn A Chung, Laurice Yang, Shu-Ching Hu and 6 more

Registry-linked trialAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Parkinsonism & related disorders, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01720810 (Pacific Northwest Udall Center), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01720810 unknown statusnot on this map

Pacific Northwest Udall Center (PANUC) Clinical Core

TypeobservationalSponsorUniversity of WashingtonRan2010 to 2025Enrolled2,000ConditionsParkinson Disease, Cognitive Impairment
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
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  6. Observational
  7. Article
  8. Associations Between Cognitive Profiles and Balance in Essential Tremor.Tremor and other hyperkinetic movements (New York, N.Y.) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Rosie MorrisDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Douglas N MartiniDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Katrijn SmuldersSint Maartenskliniek Research Department, Nijmegen, the Netherlands.
Valerie E KellyDepartment of Rehabilitation, University of Washington School of Medicine, Seattle, WA, USA.
Cyrus P ZabetianDepartment of Neurology, University of Washington School of Medicine, Seattle, WA, USA; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Kathleen PostonDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Palo Alto, CA, USA.
Amie HillerDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Kathryn A ChungDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA.
Laurice YangDepartment of Neurology and Neurological Sciences, Stanford School of Medicine, Palo Alto, CA, USA.
Shu-Ching HuDepartment of Neurology, University of Washington School of Medicine, Seattle, WA, USA; Veterans Affairs Puget Sound Health Care System, Seattle, WA, USA.
Karen L EdwardsDepartment of Epidemiology, University of California, Irvine, CA, USA.
Brenna CholertonDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA, USA.
Thomas J GrabowskiDepartment of Radiology, University of Washington School of Medicine, Seattle, WA, USA.
Thomas J MontineDepartment of Pathology, Stanford University School of Medicine, Palo Alto, CA, USA.
Joseph F QuinnDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA; Portland Veterans Affairs Health Care System, Portland, OR, USA.
Fay HorakDepartment of Neurology, Oregon Health and Science University, Portland, OR, USA; Portland Veterans Affairs Health Care System, Portland, OR, USA. Electronic address: horakf@ohsu.edu.

Funding

Oregon Clinical and Translational Research Institute - The National COVID Cohort Collaborative (N3C)UL1TR002369 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI Cynthia D Morris, Christopher G. Slatore · 2017 to 2026
$78.4M
Udall Center Director's meeting poster awardP50NS062684 · NINDS · UNIVERSITY OF WASHINGTON · PI MONTINE, THOMAS J · 2009 to 2020
$18.3M
NCATS NIH HHS UL1 TR002369NINDS NIH HHS P50 NS062684
6 · The paper itself

Abstract

introductionGait and balance impairments are cardinal features of Parkinson's disease (PD) that require cognitive input. However, the extent to which specific gait and balance characteristics relate to cognition in PD is unclear. In addition, independent models of gait and balance have not been developed from the same cohort. We aimed to i) develop models of gait and balance in a large PD cohort and ii) determine which gait and balance characteristics best related to cognition.

methodsOne hundred and ninety-eight people with PD were recruited to the Pacific Udall Center. Using six inertial sensors (APDM, Inc.), comprehensive gait measurements were collected over a 2-min continuous walk and comprehensive static balance measures were collected during a 60-second standing task. Six domains of cognition were assessed: global cognition, attention, executive function, language, memory, and visuospatial function. Correlations and hierarchical linear regression determined independent associations.

resultsPrincipal components analysis identified a gait model containing four domains accounting for 80.1% of total variance: pace/turning, rhythm, variability, and trunk. The balance model contained four independent domains accounting for 84.5% of total variance: sway area/jerkiness, sway velocity, sway frequency anteroposterior, and sway frequency mediolateral. Gait domains of pace/turning and variability were strongly associated with attention and executive function. Sway area and jerkiness of balance associated with attention and visuospatial function.

conclusionsGait and balance characteristics were associated with specific types of cognition. The specific relationships between gait or balance with cognitive functions suggests shared cerebral cortical circuitry for mobility and cognitive functions.

Indexed as

AgedCognitionCognitive DysfunctionFemaleGaitGait Disorders, NeurologicHumansMaleMiddle AgedParkinson DiseasePostural BalanceBalanceGaitNeurological disease

Identifiers

PMID31731260
PMCPMC6900452

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.