Evidence map›Paper›PMID 31731180›Full record

ArticleStem cell research2019

ROCK inhibitor increases proacinar cells in adult salivary gland organoids.

Matthew Koslow, Kevin J O'Keefe, Zeinab F Hosseini, Deirdre A Nelson, Melinda Larsen

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Stem cell research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  3. Article
  4. Article
  5. Article
  6. Article
  7. Salivary Gland Bioengineering.Bioengineering (Basel, Switzerland) · 2023
    Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Hydrogels for Salivary Gland Tissue Engineering.Gels (Basel, Switzerland) · 2022
    Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Matthew KoslowGraduate program in Molecular, Cellular, Developmental and Neural Biology, University at Albany, State University of New York, Albany, NY 12222, USA; Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA; RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Kevin J O'KeefeGraduate program in Molecular, Cellular, Developmental and Neural Biology, University at Albany, State University of New York, Albany, NY 12222, USA; Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA; RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Zeinab F HosseiniGraduate program in Molecular, Cellular, Developmental and Neural Biology, University at Albany, State University of New York, Albany, NY 12222, USA; Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA; RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Deirdre A NelsonDepartment of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA; RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA.
Melinda LarsenGraduate program in Molecular, Cellular, Developmental and Neural Biology, University at Albany, State University of New York, Albany, NY 12222, USA; Department of Biological Sciences, University at Albany, State University of New York, Albany, NY 12222, USA; RNA Institute, University at Albany, State University of New York, Albany, NY 12222, USA; Department of Biological Sciences, University at Albany, SUNY, 1400 Washington Ave., LSRB 1086, Albany, NY 12222, USA. Electronic address: mlarsen@albany.edu.
Albany State University · US

Funding

Remediating fibrosis for salivary gland regenerationR01DE027953 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI MELINDA LARSEN · 2019 to 2026
$5.4M
Engineering Functioning Salivary Glands Using Micropatterned ScaffoldsR56DE022467 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI CASTRACANE, JAMES, LARSEN, MELINDA · 2017 to 2017
$653k
Endothelial cell signaling in regenerationR21DE027571 · NIDCR · STATE UNIVERSITY OF NEW YORK AT ALBANY · PI LARSEN, MELINDA · 2018 to 2019
$432k
NIDCR NIH HHS R01 DE027953NIDCR NIH HHS R21 DE027571NIDCR NIH HHS R56 DE022467
6 · The paper itself

Abstract

Salisphere-derived adult epithelial cells have been used to improve saliva production of irradiated mouse salivary glands. Importantly, optimization of the cellular composition of salispheres could improve their regenerative capabilities. The Rho Kinase (ROCK) inhibitor, Y27632, has been used to increase the proliferation and reduce apoptosis of progenitor cells grown in vitro. In this study, we investigated whether Y27632 could be used to improve expansion of adult submandibular salivary epithelial progenitor cells or to affect their differentiation potential in different media contexts. Application of Y27632 in medium used previously to grow salispheres promoted expansion of Kit

Indexed as

Acinar CellsAmidesAnimalsAntigens, DifferentiationFemaleHumansMiceOrganoidsPyridinesrho-Associated KinasesSalivary GlandsSignal TransductionStem CellsAmidesAntigens, DifferentiationPyridinesrho-Associated KinasesY 27632OrganoidProacinar differentiationSalisphereSalivary glandY27632

Identifiers

PMID31731180
PMCPMC7069099
OpenAlexW2981285152

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.