Evidence map›Paper›PMID 31731043›Full record

ArticleNeurobiology of disease2020

Fibrotic scar after experimental autoimmune encephalomyelitis inhibits oligodendrocyte differentiation.

Stephanie L Yahn, Jiajun Li, Irene Goo, Han Gao, Roberta Brambilla, Jae K Lee

Abstract read
In one paragraph

Article in Neurobiology of disease, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

  1. The role of type I collagen in white matter injury.Anatomical science international · 2026
    Review
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  8. Detrimental influence of Arginase-1 in infiltrating macrophages on poststroke functional recovery and inflammatory milieu.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  14. The role of fibrinogen in traumatic brain injury: from molecular pathological mechanisms to clinical management.European journal of trauma and emergency surgery : official publication of the European Trauma Society · 2023
    Review
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  18. Distinct features of brain perivascular fibroblasts and mural cells revealed byJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Stephanie L YahnMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America.
Jiajun LiMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America.
Irene GooMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America.
Han GaoMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America.
Roberta BrambillaMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America.
Jae K LeeMiami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami School of Medicine, Miami, FL 33136, United States of America. Electronic address: JLee22@med.miami.edu.

Funding

Targeting Lipid Clearance Pathways to Promote Repair After SCIR01NS081040 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI Jae K Lee · 2012 to 2026
$5.3M
Translational Profile of Perivascular Fibroblasts after Spinal Cord InjuryR21NS082835 · NINDS · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI LEE, JAE K · 2013 to 2014
$420k
NINDS NIH HHS R01 NS081040NINDS NIH HHS R21 NS082835
6 · The paper itself

Abstract

Remyelination failure is a crucial component of disease progression in the autoimmune demyelinating disease Multiple Sclerosis (MS). The regenerative capacity of oligodendrocyte progenitor cells (OPCs) to replace myelinating oligodendrocytes is likely influenced by many aspects of the lesion environment including inflammatory signaling and extracellular matrix (ECM) deposition. These features of MS lesions are typically attributed to infiltrating leukocytes and reactive astrocytes. Here we demonstrate that fibroblasts also contribute to the inhibitory environment in the animal model of MS, experimental autoimmune encephalomyelitis (EAE). Using Col1α1

Indexed as

Cell DifferentiationAnimalsEncephalomyelitis, Autoimmune, ExperimentalFibroblastsFibrosisMaleMice, Inbred C57BLMice, TransgenicMyeloid CellsOligodendrogliaSpinal CordWhite MatterEAEFibrosisFibrotic scarMSMyelinationOPCsPerivascular fibroblasts

Identifiers

PMID31731043
PMCPMC7547849

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.