Evidence map›Paper›PMID 31730933›Full record

ArticleFree radical biology & medicine2020

NOX2-derived reactive oxygen species in immune cells exacerbates salt-sensitive hypertension.

Justine M Abais-Battad, Hayley Lund, John Henry Dasinger, Daniel J Fehrenbach, Allen W Cowley, David L Mattson

Abstract read
In one paragraph

Article in Free radical biology & medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Trial
  2. Review
  3. Article
  4. Article
  5. Article
  6. Reactive oxygen species in hypertension.Nature reviews. Cardiology · 2025
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Oxidative Stress, Antioxidants and Hypertension.Antioxidants (Basel, Switzerland) · 2023
    Review
  14. Review
  15. Article
  16. Review
  17. Article
  18. High NaBiomedicines · 2021
    Review
  19. Article
  20. Oxidative Stress and Hypertension.Circulation research · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Justine M Abais-BattadDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA. Electronic address: jabaisbattad@augusta.edu.
Hayley LundDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
John Henry DasingerDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Daniel J FehrenbachDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
Allen W CowleyDepartment of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.
David L MattsonDepartment of Physiology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Physiology, Medical College of Georgia at Augusta University, Augusta, GA, USA.

Funding

Therapeutic Effects of mTOR Inhibition in Salt-Sensitive HypertensionP01HL116264 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2013 to 2021
$18.7M
INTEGRATED PHYSIOLOGY TRAINING--MOLECULE TO ORGANISMT32HL007852 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI Matthew Robert Hodges · 1996 to 2026
$6.5M
Mechanisms of renal immune cell infiltration in salt-sensitive hypertensionR01HL137748 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI COWLEY, ALLEN W, MATTSON, DAVID L. · 2018 to 2021
$2.3M
Arterial Blood Pressure in eNOS Knockout MiceR01DK062803 · NIDDK · MEDICAL COLLEGE OF WISCONSIN · PI MATTSON, DAVID L. · 2003 to 2011
$2.1M
Contribution of T lymphocytes in the development of maternal syndrome in Dahl SS ratsF32HL143832 · NHLBI · AUGUSTA UNIVERSITY · PI DASINGER, JOHN H · 2019 to 2021
$134k
NADPH oxidase-mediated NLRP3 Inflammasome Activation in Dahl Salt-Sensitive HypertensionF32HL136161 · NHLBI · MEDICAL COLLEGE OF WISCONSIN · PI ABAIS-BATTAD, JUSTINE M · 2017 to 2017
$51k
NHLBI NIH HHS F32 HL136161NHLBI NIH HHS F32 HL143832NHLBI NIH HHS P01 HL116264NHLBI NIH HHS R01 HL137748NHLBI NIH HHS T32 HL007852NIDDK NIH HHS R01 DK062803
6 · The paper itself

Abstract

Previous studies utilizing the SS

Indexed as

HypertensionSodium Chloride, DietaryAnimalsBlood PressureKidneyRatsRats, Inbred DahlReactive Oxygen SpeciesReactive Oxygen SpeciesSodium Chloride, DietaryHypertensionImmune cellsNADPH oxidasep67phoxReactive oxygen speciesRenal damage

Identifiers

PMID31730933
PMCPMC6942201

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.