ArticlePLoS neglected tropical diseases2019
Sylvatic dengue virus type 4 in Aedes aegypti and Aedes albopictus mosquitoes in an urban setting in Peninsular Malaysia.
Article in PLoS neglected tropical diseases, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed.
- Neutralizing antibody evidence of dengue and chikungunya virus exposure in macaques from an urban-forest fringe in Peninsular Malaysia.Tropical medicine and health · 2026Article
- Emerging and regionally novel voltage-gated sodium channel mutations associated with pyrethroid resistance and altered binding affinity in Aedes albopictus (Skuse) from Northern Peninsular Malaysia.Parasites & vectors · 2026Article
- Chemical composition, enantiomeric distributions of chiral monoterpenoids, and Aedes mosquito control potential of Globba schomburgkii Hook.f. (Zingiberaceae) essential oil.Scientific reports · 2026Article
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- Genomic evidence links human dengue cases with undetermined serotypes to sylvatic lineages.Tropical medicine and health · 2025Article
- Spatial occurrence-intensity modeling of dengue incidence in southernmost provinces of Thailand.PLoS neglected tropical diseases · 2025Article
- Future threats: Animal orthoflaviviruses that currently infect fewer than 100 people per year.Cell reports · 2025Review
- Dengue's climate conundrum: how vegetation and temperature shape mosquito populations and disease outbreaks.BMC public health · 2025Article
- Spatiotemporal Characterization of Dengue Incidence and Its Correlation to Climate Parameters in Indonesia.Insects · 2024Article
- Potential Way to Develop Dengue Virus Detection inTropical medicine and infectious disease · 2024Review
- Detecting the impacts of humidity, rainfall, temperature, and season on chikungunya, dengue and Zika viruses in Aedes albopictus mosquitoes from selected sites in Cebu city, Philippines.Virology journal · 2024Article
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- Pathogens, reservoirs, and vectors involved in the transmission of vector-borne and zoonotic diseases in a Colombian region.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2023Article
- A fatal case of dengue hemorrhagic fever associated with dengue virus 4 (DENV-4) in Brazil: genomic and histopathological findings.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2022Article
- The practicality of Malaysia dengue outbreak forecasting model as an early warning system.Infectious Disease Modelling · 2022Article
- Intra-Host Diversity of Dengue Virus in Mosquito Vectors.Frontiers in cellular and infection microbiology · 2022Review
- A protocol for a longitudinal, observational cohort study of infection and exposure to zoonotic and vector-borne diseases across a land-use gradient in Sabah, Malaysian Borneo: a socio-ecological systems approach.Wellcome open research · 2022Article
- Genetic diversity of Dengue virus serotypes circulating amongOne health (Amsterdam, Netherlands) · 2021Article
- Multifoci and multiserotypes circulation of dengue virus in Senegal between 2017 and 2018.BMC infectious diseases · 2021Article
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6 authors.
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Abstract
Dengue fever is endemic in Malaysia, contributing to significant economic and health burden in the country. Aedes aegypti and Ae. albopictus are the main vectors of the dengue virus (DENV), which circulates in sylvatic and human transmission cycles and has been present in Malaysia for decades. The study investigated the presence and distribution of DENV in urban localities in the Klang Valley, Peninsular Malaysia. A total of 364 Ae. aegypti and 1,025 Ae. albopictus larvae, and 10 Ae. aegypti and 42 Ae. albopictus adult mosquitoes were screened for the presence of DENV. In total, 31 (2.2%) samples were positive, of which 2 Ae. albopictus larvae were co-infected with two serotypes, one with DENV-2 and DENV-3 and the other with DENV-3 and DENV-4. Phylogenetic analysis determined that the isolates belonged to DENV-1 genotype I (1 Ae. aegypti adult), DENV-2 (1 Ae. albopictus larva), DENV-3 genotype V (3 Ae. aegypti larvae and 10 Ae. albopictus larvae) and DENV-4 genotype IV (6 Ae. aegypti larvae and 12 Ae. albopictus larvae), a sylvatic strain of DENV-4 which was most closely related with sylvatic strains isolated from arboreal mosquitoes and sentinel monkeys in Peninsular Malaysia in the 1970s. All four DENV serotypes were co-circulating throughout the study period. The detection of a sylvatic strain of DENV-4 in Ae. aegypti and Ae. albopictus mosquitoes in urban areas in Peninsular Malaysia highlights the susceptibility of these vectors to infection with sylvatic DENV. The infectivity and vector competence of these urban mosquitoes to this strain of the virus needs further investigation, as well as the possibility of the emergence of sylvatic virus into the human transmission cycle.
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