Observational studyPloS one2019
Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study.
Observational study in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study.Disease markers · 2020Trial
- Risk factor analysis and predictive model construction and evaluation of fractional uric acid excretion in Chinese inpatients with type 2 diabetes.Scientific reports · 2026Article
- Increased serum uric acid-to-urinary urate excretion ratio with the kidney function decline in male CKD patients without diabetes: a retrospective cohort study.BMC nephrology · 2025Article
- Response to febuxostat according to clinical subtypes of hyperuricemia: a prospective cohort study in primary gout.Arthritis research & therapy · 2023Article
- Sex differences in the association between urate metabolism and kidney outcomes in patients with chronic kidney disease.Clinical and experimental nephrology · 2023Article
- Prevalence of Hyperuricemia and Its Association with Cardiovascular Risk Factors and Subclinical Target Organ Damage.Journal of clinical medicine · 2022Article
- Early life body mass index trajectories and albuminuria in midlife: A 30-year prospective cohort study.EClinicalMedicine · 2022Article
- Associations of Long-Term Visit-to-Visit Blood Pressure Variability With Subclinical Kidney Damage and Albuminuria in Adulthood: a 30-Year Prospective Cohort Study.Hypertension (Dallas, Tex. : 1979) · 2022Article
- Associations of Renalase With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2022Article
- Development and Validation of Prediction Models for Hypertensive Nephropathy, the PANDORA Study.Frontiers in cardiovascular medicine · 2022Article
- Associations of plasma uromodulin and genetic variants with blood pressure responses to dietary salt interventions.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Lipidomics study of the therapeutic mechanism of Plantaginis Semen in potassium oxonate-induced hyperuricemia rat.BMC complementary medicine and therapies · 2021Article
- Blood pressure and long-term subclinical cardiovascular outcomes in low-risk young adults: Insights from Hanzhong adolescent hypertension cohort.Journal of clinical hypertension (Greenwich, Conn.) · 2021Article
- Child-to-adult body mass index trajectories and the risk of subclinical renal damage in middle age.International journal of obesity (2005) · 2021Article
- Risk factors for subclinical renal damage and its progression: Hanzhong Adolescent Hypertension Study.European journal of clinical nutrition · 2021Article
- Associations of Serum Uromodulin and Its Genetic Variants With Blood Pressure and Hypertension in Chinese Adults.Frontiers in cardiovascular medicine · 2021Article
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Authors and funding
19 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesThe aim of the study was to examine the associations of uric acid (UA) in blood and urine with subclinical renal damage (SRD) and its progression in a Chinese cohort.
methods1) 2342 participants from our previously established cohort who were followed up in 2017 were included. Cross-sectional analysis was used to examine the relationships between serum and urinary UA and the risk of SRD. 2) A total of 266 participants were recruited from the same cohort in 2013, and followed up in 2017. Longitudinal analysis was used to determine the relationships of serum and urinary UA with progression of SRD, which was defined as urinary albumin-to-creatinine ratio (uACR) progression or estimated glomerular filtration rate (eGFR) decline.
resultsIn cross-sectional analysis, higher levels of uACR were associated with higher levels of serum uric acid (SUA) and urinary uric acid/creatinine ratio (uUA/Cre). Lower eGFR was associated with higher levels of SUA and fractional excretion of uric acid (FEUA) but lower uUA/Cre levels in all subjects. In addition, the multivariate-adjusted odds ratios for SRD compared with non-SRD were 3.574 (2.255-5.664) for uUA/Cre. Increasing uUA/Cre levels were associated with higher risk of SRD. In longitudinal analysis, 4-year changes of uUA/Cre and SUA were significantly associated with eGFR decline.
conclusionsThis study suggested that urinary UA excretion was significantly associated with the risk of SRD in Chinese adults. Furthermore, 4-year changes of serum and urinary UA were associated with SRD progression. These findings suggest that UA, especially urinary UA, may be used as a simple, noninvasive marker for early detection of decreased renal function in otherwise healthy subjects.
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