Evidence map›Paper›PMID 31730503›Full record

ArticleJournal for immunotherapy of cancer2019

Dual checkpoint inhibitor-associated eosinophilic enteritis.

J Yang, S M Lagana, Y M Saenger, R D Carvajal

Abstract readCase Reports
In one paragraph

Article in Journal for immunotherapy of cancer, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

J YangDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
S M LaganaDepartment of Pathology and Cell Biology, Columbia University Irving Medical Center, New York, NY, USA.
Y M SaengerDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
R D CarvajalDepartment of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA. rdc2150@cumc.columbia.edu.ORCID 0000-0002-3796-1118

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundEosinophilia has been reported as a rare, new biological effect of immune checkpoint inhibition that may be associated with improved treatment response and the development of immune-related adverse events. CASE PRESENTATION: We report a case of dual checkpoint inhibitor-associated hypereosinophilia and eosinophilic enteritis in a patient with advanced cutaneous melanoma. Rapid resolution of peripheral eosinophilia and associated symptoms was achieved with steroids alone.

conclusionsImmune checkpoint inhibition can trigger inflammation in virtually any organ in the body, leading to diverse clinical manifestations. To our knowledge, this is the first case report of eosinophilic enteritis due to ipilimumab plus nivolumab.

Indexed as

AgedAntineoplastic Agents, ImmunologicalAntineoplastic Combined Chemotherapy ProtocolsEnteritisEosinophiliaGastritisHumansIpilimumabMaleMelanomaNivolumabPrednisoneSkin NeoplasmsAntineoplastic Agents, ImmunologicalIpilimumabNivolumabPrednisoneCheckpoint inhibitionEosinophiliaEosinophilic enteritisMelanoma

Identifiers

PMID31730503
PMCPMC6858706

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.