Evidence map›Paper›PMID 31730466›Full record

Observational studyBMC medical imaging2019

Localising occult prostate cancer metastasis with advanced imaging techniques (LOCATE trial): a prospective cohort, observational diagnostic accuracy trial investigating whole-body magnetic resonance imaging in radio-recurrent prostate cancer.

Sola Adeleke, Arash Latifoltojar, Harbir Sidhu, Myria Galazi, Taimur T Shah, Joey Clemente, Reena Davda, Heather Ann Payne, Manil D Chouhan, Maria Lioumi and 15 more

Registry-linked trialOpen access · goldAbstract readComparative StudyMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in BMC medical imaging, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02935816 (Whole Body Multi---Parametric MRI), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02935816 unknown statusnot on this map

Whole Body Multi---Parametric MRI: Accuracy in Staging of Biochemically Relapsed Prostate Cancer

TypeobservationalSponsorUniversity College, LondonRan2015 to 2018Enrolled130ConditionsProstate CancerArmsWhole body MRI
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

25 authors at 10 institutions in 1 country.

Sola AdelekeCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK.
Arash LatifoltojarCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK.
Harbir SidhuCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK.
Myria GalaziMolecular Oncology Group, University College London, Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Taimur T ShahDivision of Surgery and Interventional Science, University College London, 4th floor, 21 University Street, London, WC1E, UK.
Joey ClementeCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK.
Reena DavdaOncology Department, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.
Heather Ann PayneOncology Department, University College London Hospital, 235 Euston Road, London, NW1 2BU, UK.
Manil D ChouhanCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK.
Maria LioumiComprehensive Cancer Imaging Centre (CCIC), King's College, London, New Hunt's House, Guy's Campus, London, SE1 1UL, UK.
Sue ChuaDepartment of Nuclear Medicine, The Royal Marsden Hospital NHS Foundation Trust, Down's Road, Sutton, SM2 5PT, UK.
Alex FreemanHistopathology Department, University College London Hospital, 4th Floor, Rockefeller Building University Street, London, WC1 6DE, UK.
Manuel Rodriguez-JustoHistopathology Department, University College London Hospital, 4th Floor, Rockefeller Building University Street, London, WC1 6DE, UK.
Anthony CoolenInstitute for Mathematical and Molecular Biomedicine, King's College London, Hodgkin Building, Guy's Campus, London, SE1 1UL, UK.
Sachin VadgamaDepartment of Applied Health Research, University College London, 1-19 Torrington Place, Fitzrovia, London, WC1E 7HB, UK.
Steve MorrisDepartment of Applied Health Research, University College London, 1-19 Torrington Place, Fitzrovia, London, WC1E 7HB, UK.
Gary J CookDepartment of Cancer Imaging, School of Biomedical Engineering and Imaging Sciences, King's College London, 4th Floor, Lambeth Wing St. Thomas' Hospital, London, SE1 7EH, UK.
Jamshed BomanjiInstitute of Nuclear Medicine, University College London Hospital, 5th Floor Tower, 235 Euston Road, London, NW1 2BU, UK.
Manit AryaUrology Department, University College Hospital, Westmoreland Street, 16-18 Westmoreland Street, London, W1G 8PH, UK.
Simon ChowdhuryOncology Department, Guy's and St. Thomas' Hospital, Westminster Bridge road, Lambeth, London, SE1 7EH, UK.
Simon WanInstitute of Nuclear Medicine, University College London Hospital, 5th Floor Tower, 235 Euston Road, London, NW1 2BU, UK.
Athar HaroonDepartment of Nuclear Medicine, St Bartholomew's Hospital, West Smithfield, London, EC1A 7BE, UK.
Tony NgMolecular Oncology Group, University College London, Cancer Institute, Paul O'Gorman Building, 72 Huntley Street, London, WC1E 6DD, UK.
Hashim Uddin AhmedDivision of Surgery, Department of Surgery and Cancer, Faculty of Medicine, Imperial College London, London, UK.
Shonit PunwaniCentre for Medical Imaging, University College London, 2nd floor Charles Bell house, 43-45 Foley Street, London, W1W 7TS, UK. shonit.punwani@gmail.com.
University College London · GBUniversity College Hospital · GBKing's College London · GBImperial College Healthcare NHS Trust · GBImperial College London · GBLondon Cancer · GBRoyal London Hospital · GBRoyal Marsden Hospital · GBSt Bartholomew's Hospital · GBSt Thomas' Hospital · GB

Funding

Cancer Research UK 16463Cancer Research UK 27066Cancer Research UK C1519/A16463Prostate Cancer UK PG13-026
6 · The paper itself

Abstract

backgroundAccurate whole-body staging following biochemical relapse in prostate cancer is vital in determining the optimum disease management. Current imaging guidelines recommend various imaging platforms such as computed tomography (CT), Technetium 99 m ( METHODS/

designThe LOCATE trial is a prospective cohort, multi-centre, non-randomised, diagnostic accuracy study comparing WB-MRI and conventional imaging. Eligible patients will undergo WB-MRI in addition to conventional imaging investigations at the time of BCR and will be asked to attend a second WB-MRI exam, 12-months following the initial scan. WB-MRI results will be compared to an enhanced reference standard comprising all the initial, follow-up imaging and non-imaging investigations. The diagnostic performance (sensitivity and specificity analysis) of WB-MRI for re-staging of BCR will be investigated against the enhanced reference standard on a per-patient basis. An economic analysis of WB-MRI compared to conventional imaging pathways will be performed to inform the cost-effectiveness of the WB-MRI imaging pathway. Additionally, an exploratory sub-study will be performed on blood samples and exosome-derived human epidermal growth factor receptor (HER) dimer measurements will be taken to investigate its significance in this cohort. DISCUSSION: The LOCATE trial will compare WB-MRI versus the conventional imaging pathway including its cost-effectiveness, therefore informing the most accurate and efficient imaging pathway.

trial registrationLOCATE trial was registered on ClinicalTrial.gov on 18th of October 2016 with registration reference number NCT02935816.

Indexed as

Cost-Benefit AnalysisErbB ReceptorsExosomesHumansMagnetic Resonance ImagingMaleNeoplasm MetastasisNeoplasm Recurrence, LocalProspective StudiesProstatic NeoplasmsSensitivity and SpecificityWhole Body ImagingEGFR protein, humanErbB ReceptorsBrachytherapyCost comparisonCost-effectivenessEconomic evaluationMagnetic resonance imagingPositron emission tomographyProstate cancerRadiotherapyRecurrence

Identifiers

PMID31730466
PMCPMC6858718
OpenAlexW2984474506

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.