Observational studyJournal of global oncology2019
Advanced Stage at Diagnosis and Worse Clinicopathologic Features in Young Women with Breast Cancer in Brazil: A Subanalysis of the AMAZONA III Study (GBECAM 0115).
Observational study in Journal of global oncology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02663973 (Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III), which is not on this map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Prospective Evaluation of Breast Cancer at Brazilian Institutions - Project AMAZONA III
Who cites it
25 citing papers in PubMed.
- Disparities in breast cancer screening, stage at diagnosis, and treatment in Brazil: a warning of the need to change public policies.BMC public health · 2026Article
- Overall survival of patients with second primary breast cancer associated with molecular subtype and epidemiological profile at a cancer center.Breast cancer (Tokyo, Japan) · 2026Article
- Impact of public vs. private insurance coverage on quality of life of women with early-stage estrogen receptor-positive breast cancer.Breast cancer research and treatment · 2025Article
- Article
- Breast cancer patterns by age groups in Brazil: insights from population-based registries data.BMC cancer · 2025Article
- Relationship between diagnostic characteristics, lifestyle habits and breast cancer subtypes in women.Revista latino-americana de enfermagem · 2025Article
- Epidemiological profile of breast cancer in a reference center in the north region of Brazil.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025Article
- Comprehensive diagnosis of advanced-stage breast cancer: exploring detection methods, molecular subtypes, and demographic influences - A cross-sectional study.Clinics (Sao Paulo, Brazil) · 2024Article
- The HER2 flip-HER2 amplification of tumor cells in the cerebrospinal fluid of breast cancer patients with leptomeningeal disease: implications for treating the LM tumor with anti-HER2 therapy.Frontiers in oncology · 2024Article
- The somatic mutation profile of estrogen receptor-positive HER2-negative metastatic breast cancer in Brazilian patients.Frontiers in oncology · 2024Article
- Epidemiological and Clinical Characteristics of Young Patients With Breast Cancer in Brazil: A Retrospective Study.JCO global oncology · 2023Article
- Recommendations for the Screening of Breast Cancer of the Brazilian College of Radiology and Diagnostic Imaging, Brazilian Society of Mastology and Brazilian Federation of Gynecology and Obstetrics Association.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2023Article
- Overall survival and associated factors in women with metastatic breast cancer treated with trastuzumab at a public referral institution.Revista brasileira de epidemiologia = Brazilian journal of epidemiology · 2023Article
- Breast and gynecologic cancers as a Brazilian health priority.Revista da Associacao Medica Brasileira (1992) · 2023Review
- Is using the Gail model to calculate the risk of breast cancer in the Venezuelan population justified?Ecancermedicalscience · 2023Review
- Overall survival analyses of female malignancies in Southern Brazil during 2008-2017: A closer look at breast, cervical and ovarian cancer.Dialogues in health · 2022Review
- Clinicopathological features and BRCA1 and BRCA2 mutation status in a prospective cohort of young women with breast cancer.British journal of cancer · 2022Article
- Article
- Cost-effectiveness of ribociclib for premenopausal or perimenopausal women with HR+/HER2- advanced breast cancer: a Brazilian public health care system perspective.Therapeutic advances in medical oncology · 2022Article
- Do prognosis and clinicopathological features differ in young early-stage breast cancer?Frontiers in surgery · 2022Article
Corrections and comments
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Authors and funding
29 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeBreast cancer (BC) in young women is uncommon and tends to present with more aggressive characteristics. To better understand and characterize this scenario in Brazil through real-world data, we performed a subanalysis of AMAZONA III study (ClinicalTrials.gov identifier: NCT02663973).
methodsThe AMAZONA III study (GBECAM 0115) is a prospective registry that included 2,950 women newly diagnosed with invasive BC in Brazil from January 2016 until March 2018 at 22 sites. Valid data were obtained from 2,888 patients regarding age at diagnosis and complete baseline information. To compare epidemiologic and clinicopathological features at the time of diagnosis, patients with BC were divided into two groups according to age: ≤ 40 years and > 40 years. Quantitative variables were described as means, and categorical variables were described as frequencies and percentages and compared using the Pearson's χ
resultsOf 2,888 women diagnosed with BC, 486 (17%) were ≤ 40 years old. Young women had higher educational level, most were employed and a significant number were married (
conclusionBrazilian women younger than age 40 years have unfavorable clinicopathological features of BC at diagnosis, with more aggressive subtypes and advanced stage when compared with older women. These differences are not explained by socioeconomic or ethnic imbalances. The causes of a higher prevalence of BC among young women in Brazil deserve additional investigation.
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