ArticleACS nano2019
Dendritic Cell-Activating Magnetic Nanoparticles Enable Early Prediction of Antitumor Response with Magnetic Resonance Imaging.
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Article in ACS nano, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.
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42citing papers in PubMed
3.8field-weighted citation impact, top 6% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
42 citing papers in PubMed, 91 citations in OpenAlex.
- The promise of immunotherapy for central nervous system tumours.Nature reviews. Immunology · 2026Review
- Magnetic nanoparticles as promising materials for the future of medicine.Journal of materials science. Materials in medicine · 2026Review
- Innovative gene engineering and drug delivery systems for dendritic cells in cancer immunotherapy.Journal of biomedical science · 2025Review
- Nanotechnology for immuno-oncology.Nature cancer · 2025Review
- Therapeutic mRNA vaccine applications in oncology.Molecular therapy : the journal of the American Society of Gene Therapy · 2025Review
- Harnessing Biomarker Activatable Probes for Early Stratification and Timely Assessment of Therapeutic Efficacy in Cancer.Exploration (Beijing, China) · 2025Review
- Iron Oxide Magnetic Nanoparticles Synthesized by Laser Target Evaporation Method for the Needs of Cancer Immunotherapy.Materials (Basel, Switzerland) · 2025Article
- Potential mechanisms and clinical applications of static magnetic field therapy in glioma.Frontiers in neurology · 2025Review
- Adjuvants for cancer mRNA vaccines in the era of nanotechnology: strategies, applications, and future directions.Journal of nanobiotechnology · 2024Review
- Targeting lymph nodes for enhanced cancer vaccination: From nanotechnology to tissue engineering.Materials today. Bio · 2024Review
- Nanotechnology's frontier in combatting infectious and inflammatory diseases: prevention and treatment.Signal transduction and targeted therapy · 2024Review
- mRNA-based precision targeting of neoantigens and tumor-associated antigens in malignant brain tumors.Genome medicine · 2024Article
- Inorganic Nanoparticle Functionalization Strategies in Immunotherapeutic Applications.Biomaterials research · 2024Review
- Bacteria-derived extracellular vesicles: endogenous roles, therapeutic potentials and their biomimetics for the treatment and prevention of sepsis.Frontiers in immunology · 2024Review
- Review
- Multifunctional magnetic nanoparticles elicit anti-tumor immunity in a mouse melanoma model.Materials today. Bio · 2023Article
- mRNA-based vaccines and therapeutics: an in-depth survey of current and upcoming clinical applications.Journal of biomedical science · 2023Review
- Nanoformulations targeting immune cells for cancer therapy: mRNA therapeutics.Bioactive materials · 2023Article
- Prospects for the Use of Metal-Based Nanoparticles as Adjuvants for Local Cancer Immunotherapy.Pharmaceutics · 2023Review
- Omniparticle Contrast Agent for Multimodal Imaging: Synthesis and Characterization in an Animal Model.Molecular imaging and biology · 2023Article
Corrections and comments
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Authors and funding
15 authors at 2 institutions in 1 country.
Adam J GrippinPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.ORCID 0000-0002-8076-4240
Brandon WummerPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Tyler WildesPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.ORCID 0000-0001-8313-9144
Kyle DysonPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Vrunda TrivediPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Changlin YangPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Mathew SebastianPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Hector R Mendez-GomezPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Suraj PadalaPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Mackenzie GrubbJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering , University of Florida , 1275 Center Drive , Gainesville , Florida 32611-7011 , United States.
Matthew FillingimPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Adam MonsalveJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering , University of Florida , 1275 Center Drive , Gainesville , Florida 32611-7011 , United States.
Elias J SayourPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Jon DobsonJ. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering , University of Florida , 1275 Center Drive , Gainesville , Florida 32611-7011 , United States.
Duane A MitchellPreston A. Wells, Jr. Center for Brain Tumor Therapy, UF Brain Tumor Immunotherapy Program, Lillian S. Wells Department of Neurosurgery, McKnight Brain Institute , University of Florida , 1149 Newell Drive , P.O. Box 10026, Gainesville , Florida 32610 , United States.
Allen Institute for Brain Science · USUniversity of Florida · US
Funding
Together: Transforming and Translating Discovery to Improve HealthTL1TR001428 · NCATS · UNIVERSITY OF FLORIDA · PI MCCORMACK, WAYNE T. · 2015 to 2023
$3.9MEfficacy of Dendritic Cell Vaccines Targeting CMV in Glioblastoma (phase 2 DC vaccine)R01CA175517 · NCI · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A., SAMPSON, JOHN H. · 2015 to 2020
$3.1MEnhancing Adoptive Immunotherapy Targeting Pediatric High-Grade GliomasR01CA195563 · NCI · UNIVERSITY OF FLORIDA · PI MITCHELL, DUANE A., PACKER, ROGER · 2015 to 2019
$2.8MHarnessing the Immunologic Capacity of RNA-nanoparticle Vaccines Targeting GlioblastomaK08CA199224 · NCI · UNIVERSITY OF FLORIDA · PI SAYOUR, ELIAS · 2016 to 2020
$791kPglyrp3 cooperates with Snail1 to mediate anti-tumor immune response in breast cancerF30CA232641 · NCI · UNIVERSITY OF FLORIDA · PI SEBASTIAN, MATHEW · 2018 to 2021
$179kEngineering RNA-nanoparticles to enhance dendritic cell mediated treatment of glioblastomaF30CA228280 · NCI · UNIVERSITY OF FLORIDA · PI GRIPPIN, ADAM · 2018 to 2020
$140kNCATS NIH HHS TL1 TR001428NCI NIH HHS F30 CA228280NCI NIH HHS F30 CA232641NCI NIH HHS K08 CA199224NCI NIH HHS R01 CA175517NCI NIH HHS R01 CA195563
Abstract
Cancer vaccines initiate antitumor responses in a subset of patients, but the lack of clinically meaningful biomarkers to predict treatment response limits their development. Here, we design multifunctional RNA-loaded magnetic liposomes to initiate potent antitumor immunity and function as an early biomarker of treatment response. These particles activate dendritic cells (DCs) more effectively than electroporation, leading to superior inhibition of tumor growth in treatment models. Inclusion of iron oxide enhances DC transfection and enables tracking of DC migration with magnetic resonance imaging (MRI). We show that
Indexed as
Magnetic Resonance ImagingAnimalsAntineoplastic AgentsBiomarkers, TumorCancer VaccinesCell Line, TumorCell MovementCell TrackingDendritic CellsElectroporationFerric CompoundsMagnetite NanoparticlesMice, Inbred C57BLTransfectionAntineoplastic AgentsBiomarkers, TumorCancer VaccinesFerric Compoundsferric oxideMagnetite Nanoparticlesbiomarkercancercancer immunotherapydendritic cellsiron oxideliposomenanoparticleRNARNA-lipoplexvaccine
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.